Articulo
Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons.
FRONTIERS IN AGING NEUROSCIENCE
Autor
Castro, P. A.
Ramirez, A.
Sepúlveda, F. J.
Peters, C.
Fierro, H.
Waldron, J.
Luza, S.
Fuentealba, J.
Muñoz, F. J.
De Ferrari, G. V.|Bush, A. I.
Aguayo, L. G.
Opazo, C. M.
Institución
Resumen
Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality and human behavior. We have found that a metal coordinating molecule, Neocuproine, transiently increases free intracellular cop FONDAP FONDAP