Articulo
Carbon monoxide impairs mitochondria-dependent endosomal maturation and antigen presentation in dendritic cells
European journal of immunology
Registro en:
1140010
1140010
Autor
Riquelme, Sebastián A
Pogu, Julien
Anegon, Ignacio
Bueno-Ramirez, Susan Marcela
Kalergis-Parra, Alexis Mikes
Institución
Resumen
Heme-oxygenase 1 (HO-1) prevents T cell-mediated inflammatory disease by producing carbon monoxide (CO) and impairing DC immunogenicity. However, the cellular mechanisms causing this inhibition are unknown. Here, we show that CO impairs mitochondrial func National Research Agency via the investment of the future program [ANR-11-LABX-0016-01, ANR-10-IBHU-005]; Institut Hospitalo-Universitaire-Centre Europeen des Sciences de la Transplantation et Immunotherapi projectRegion Pays de la Loire; French Governmen FONDECYT FONDECYT