Articulo
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent
Blood
Autor
Xiang, M.
Kim, H.
Ho, V. T.
Walker, S. R.
Bar-Natan, M.
Anahtar, M.
Liu, S.
Toniolo, P. A.
Kroll, Y.
Jones, N.
Giaccone, Z. T.
Heppler, L. N.
Ye, D. Q.
Marineau, J. J.
Shaw, D.
Bradner, J. E.
Blonquist, T.
Neuberg, D.
Hetz, C.
Stone, R.
Institución
Resumen
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated inappropriately in a wide range of hematological and solid cancers, but clinically available therapies targeting STAT3 are lacking. Using FONDAP FONDAP