Articulo
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies
PEERJ
Registro en:
1140553
1140553
Autor
Lord, Phillip
Spiering, Rachel
Aguillón-Gutiérrez, Juan Carlos
Anderson, Amy E
Appel, Silke
Benitez-Ribas, Daniel
ten Brinke, Anja
Broere, Femke
Broere, Femke
Cools, Nathalie
Cuturi, Maria Cristina
Institución
Resumen
Abstract. Cellular therapies, with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application. Keywords. Author Keywords:Cell therapy; Minimum information model; Antigen-presenting cells; Autoimmune disease; Transplantation; Tolerogenic dendritic cells; Regulatory macrophages; Reporting guidelines