Articulo
Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability
Reproduction, Fertility and Development
Autor
Busso, Dolores
Oñate-Alvarado, María José
Balboa, Elisa
Castro, Juan
Lizama, Carlos
Morales, Gabriela
Vargas, Susana
Hartel, Steffen
Moreno, Ricardo
Zanlungo, Silvana
Institución
Resumen
The cholesterol content of the sperm membrane is regulated during both maturation in the epididymis and capacitation in the female tract, two processes required for the spermatozoa to acquire their fertilising ability. Because Niemann-Pick disease, type C FONDAP FONDAP