Ponencia
Vitamin D deficiency and its association with falls and morbility in chilean older people
Autor
Albala, Cecilia
Angel-Badillo, Barbara Karen
Cea, Ximena
Lera, Lydia
Sánchez, Hugo
Institución
Resumen
bone heallh, deficiency of _ D has been assoaatOO witIJcancer. diabetes, hypertensJO(l,
cardiovascuIar disease and al cause mortaJity. Insufficient vitamin O in oIder aduIIs is associatOO Biso wiIh
-.g abiIiIy.muscIe weakness and subsequent faIs and lracfures .' ..
Dbjectivoo: ro study /he associalion 01 vilamin O deficiency ItIitI!mobiIity anrJ falls 111 commumty-living
::~:e seclionaJ study in 970 community living subjects 60-921 (665 women) residing in Sanliego,
Chile. Plasma _ of 25-hycJroxyvilamin O (V'IID) were determined by radíoimmUnOasSay. 5eIt reportOO
funcIionaI 1imitaJions. chronic diseases and falls were regislered. An1hropometry, hand grip s/!ellglh and
Trned '" end go (TUG) lesI werc messured. VitO deliciency was defined as <50. nmo/lt and severa
-.:y as VitD<25 __ 0pI*naI VilO was defined as >75 nmoI1.. LogisIíCregressKXIwas performed /O
adjusl/he associalion 01 V'dO witIJfuncIionaIlimitalions, lalls and TUG.
Results: '{1tIJ def1c:iency was similar in both men and women (43.go¡; VS 46.20/.) but severe deficiency was
higherin women /han in men (11.9% vs 7.5" •• p<O.05). The lime (seconds) lo pertorm TUG was 10.80t5.S/or
peopIe wilh VitD<25nmo111. 8.9±4.S lor VitO 25-49nmol, 8.3 ,;2.6 for VdD50-74 nmoVL and 7.6ú'.3 lor
VilD>75nnJom (p<D.OOO1). Alter adjusting by dinamometry, age, gender and BMI, VitD<25nnJom was
associated wiIh funcIionaIlimilation (0R4_3; 95= 1.26-4.08) and taRs (00= 1.57; 95%Cf 1.03-2.39). Alter
adjusIing a dose- response relalion was obsBrvOO belWeen categories of serum vilD and TUG Bbove 10See
(VitD<25nmo/lL 00= 8.6. 95%C14.13-18.08; Vit D 25-49nmo111. OR= 4.0,95= 2.11·7.58; V~ D 50-74
nmoVL 00= 2. 9S%Cll.03-3.97). A serum vitO >75 nmollL (OR=0.6S, 95~1.C10.42-0.99) and a cinamometry
above p7S (00= 0.97, 95%C1 0.95-0.99) lVere protec1ive/or faHs
ConcIuolono: Vitamin D <75nmotll. was slrongly associaled witIJTUG=IDseconds. Severe VHO deliciency
was aIso associalOO with falls and funclional fimilalions in oIder peopIe. Normal levels of Vd O and
ditamometry >p25 ""'" proIectivB factors for faJIs