Articulo
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model
Scientific reports
Autor
Bargsted, L.
Medinas, D. B.
Martínez-Traub, F.
Rozas, P.
Muñoz, N.
Nassif, M.
Jerez, C.
Catenaccio, A.
Court, F. A.
Hetz, C.
Matus, S.
Institución
Resumen
Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Previous studies described a TDP-43A3 FONDAP FONDAP