Articulo
Infralimbic cortex activation and motivated arousal induce histamine release
Behavioural Pharmacology
Registro en:
1130042
1130042
Autor
Riveros, María Eugenia
Forray, María Ines
Torrealba-López, Fernando
Institución
Resumen
Appetitive behaviours occur in a state of behavioural and physiological activation that allows the optimal performance of these goal-directed behaviours. Here, we tested the hypothesis that histamine neurons under the command of the infralimbic cortex are important to provide behavioural activation. Extracellular histamine and serotonin were measured by microdialysis of the medial prefrontal cortex in behaving rats in parallel with a picrotoxin microinjection into the infralimbic cortex. The injection aroused the rats behaviourally, increased histamine release and decreased serotonin levels. Inhibition of the infralimbic cortex with muscimol produced the opposite effects on neurotransmitter release. The behavioural activation induced by motivating hungry rats with caged food was paralleled by an immediate histamine release, whereas awakening induced by tapping their microdialysis bowl increased serotonin, but not histamine levels. In conclusion, picrotoxin injection into the infralimbic cortex produces behavioural activation together with histamine release; in a similar manner, induction of an appetitive state produced histamine release, likely related to increased behavioural activation characteristic of an appetitive behaviour. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. Keywords. Author Keywords:appetitive behaviour; arousal; microdialysis; motivation; Sprague-Dawley