Articulo
Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation
JOURNAL OF CHEMISTRY
Registro en:
1150712
1150712
Autor
Treuer, Adriana V
De La Torre, Pedro
Gutierrez-Cabrera, Margarita Isabel
Institución
Resumen
Given the broad spectrum of biological uses of heteroaryl-acrylonitrile derivatives, it is necessary to find simple methods to synthesize and diversify this family of compounds. We report a stereoselective synthesis of a series of new (E)-2-(1H-indole-3ylcarbonyl)-3-heteroaryl-acrylonitriles (3a-3i) obtained from 3-(cyanoacetyl) indole and heteroaryl-aldehydes under microwaveassisted Knoevenagel reaction at 300 W of potency and 100 degrees C. The desired derivatives (3a-3i) were obtained with variable yields (30-94%) and time reactions (8-90 min). All the heteroaryl-acrylonitriles were characterized by physicoanalytical techniques such IR, H-1, C-13 NMR, and electrospray mass spectrometry. Regular 2015 FONDECYT FONDECYT