Articulo
Knots can impair protein degradation by atp-dependent proteases
Proceedings Of The National Academy Of Sciences Of The United States Of America
Registro en:
1151274
1151274
Autor
San Martin, Alvaro
Rodriguez-Aliaga, Piere
Alejandro Molina, Jose
Martin, Andreas
Bustamante, Carlos
Baez, Mauricio
Institución
Resumen
ATP-dependent proteases translocate proteins through a narrow pore for their controlled destruction. However, how a protein substrate containing a knotted topology affects this process remains unknown. Here, we characterized the effects of the trefoil-kn Regular FONDECYT FONDECYT