| dc.creator | Lorca-Ponce, Enrique | |
| dc.creator | Lara-Suzarte, Marcelo Andrés | |
| dc.creator | Loyola, S | |
| dc.creator | Pino, D | |
| dc.creator | Rojas-Montecinos, Patricio Alejandro | |
| dc.date | 2018-09-21T12:13:54Z | |
| dc.date | 2022-06-18T19:25:07Z | |
| dc.date | 2018-09-21T12:13:54Z | |
| dc.date | 2022-06-18T19:25:07Z | |
| dc.date | 2013-10-04 | |
| dc.date | 2013 | |
| dc.date | 2013-10-01 | |
| dc.date.accessioned | 2023-08-21T21:44:46Z | |
| dc.date.available | 2023-08-21T21:44:46Z | |
| dc.identifier | 1130904 | |
| dc.identifier | https://hdl.handle.net/10533/220593 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8286195 | |
| dc.description | Schizophrenia is one of the most common
neurological diseases in human population,
however there is no common hypothesis to
explaining all its features. This is due in part to a
inability of animal models to reproduce all the
features observed in human patients. In this work
we use Ketamine administration to generate a
schizophrenia and psychosis-like animal model.
Adult animals (7 weeks old) were injected
intraperitoneally with of Ketamine (30 mgr/kgr) for
five days. After two days locomotor activity showed
to be significative higher than in control animals,
as showed in other animal models. Because
Hippocampus is one of the brain regions that
showed alteration in this disease, Extracellular
field recordings of the CA3-CA1 synapse were
performed to evaluate the circuit excitability. In
addition, Ketamine treated animals showed a
decrease in the Input-Output relationship of
Excitatory Post Synaptic Potentials (EPSP). In
order to test the hypothesis that a decrease in
inhibition can explain part of this pathology, we are
assaying the function of the chloride co-transporter
NKCC1, which modifies the excitation to inhibition
balance due to GABA release. In summary, we
validated the ketamine model by using both
behavioral and electrophysiological methods and
propose its usefullnes for studied of schizophrenia
and psichosis-like disorders. | |
| dc.language | eng | |
| dc.relation | instname: Conicyt | |
| dc.relation | reponame: Repositorio Digital RI2.0 | |
| dc.relation | Reunión Anual Sociedad Chilena de Neurociencias | |
| dc.relation | 9 | |
| dc.relation | info:eu-repo/grantAgreement//1130904 | |
| dc.relation | info:eu-repo/semantics/dataset/hdl.handle.net/10533/93486 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.title | Chloride transporte NKCC1 involvment in reduced excitability in an animal model of schizophrenia | |
| dc.type | Ponencia | |
| dc.type | info:eu-repo/semantics/lecture | |
| dc.coverage | Valparaíso | |
