Measuring and validation for isothermal solubility data of solid 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one (nobiletin) in supercritical carbon dioxide

JOURNAL OF CHEMICAL THERMODYNAMICS

dc.creatorCabrera-Palacios, Adolfo Luis
dc.creatorToledo, Alma R
dc.creatorDel Valle-Lladser, José Manuel
dc.creatorDe La Fuente-Badilla, Juan Carol
dc.date2021-08-23T22:52:01Z
dc.date2022-07-08T20:31:35Z
dc.date2021-08-23T22:52:01Z
dc.date2022-07-08T20:31:35Z
dc.date2015
dc.date.accessioned2023-08-21T20:51:33Z
dc.date.available2023-08-21T20:51:33Z
dc.identifier1150822
dc.identifier1150822
dc.identifierhttps://hdl.handle.net/10533/250887
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8280784
dc.descriptionIsothermal solubility of 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one (nobiletin) in supercritical carbon dioxide at temperatures of (313, 323 and 333) K and pressures from (18 to 31) MPa was measured using an analytic-recirculation methodology, with direct determination of the molar composition of the carbon dioxide-rich phase by using high performance liquid chromatography. Results indicated that the range of the measured solubility of nobiletin was from 107 . 10(-6) mol . mol(-1) at T = 333 K and 18.35 MPa to 182 . 10(-6) mol . mol(-1) at T = 333 K and 31.40 MPa, with a temperature crossover around 18 MPa. The validation of the experimental solubility data was carried out by using three approaches, namely, estimation of combined expanded uncertainty for each solubility data point from experimental parameters values (<= 77 . 10(-6) mol . mol(-1)); thermodynamic consistency, verified utilizing a test adapted from tools based on Gibbs-Duhem equation and solubility modelling results; and, self-consistency, proved by correlating the solubility data with a semi-empirical model as a function of temperature, pressure and pure CO2 density. (C) 2015 Elsevier Ltd. All rights reserved.
dc.descriptionRegular 2015
dc.descriptionFONDECYT
dc.descriptionFONDECYT
dc.languageeng
dc.relationhandle/10533/111557
dc.relationhandle/10533/111541
dc.relationhandle/10533/108045
dc.relationhttps://doi.org/10.1016/j.jct.2015.08.018
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsinfo:eu-repo/semantics/article
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMeasuring and validation for isothermal solubility data of solid 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one (nobiletin) in supercritical carbon dioxide
dc.titleJOURNAL OF CHEMICAL THERMODYNAMICS
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/publishedVersion


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