Tanycytes and the control of thyrotropin-releasing hormone flux into portal capillaries

dc.creatorRodríguez-Rodríguez, Adair
dc.creatorLazcano, Iván
dc.creatorSánchez-Jaramillo, Edith
dc.creatorUribe, Rosa María
dc.creatorJaimes-Hoy, Lorraine
dc.creatorJoseph-Bravo, Patricia
dc.creatorCharli, Jean-Louis
dc.date2019
dc.date2019
dc.date.accessioned2023-07-25T16:00:53Z
dc.date.available2023-07-25T16:00:53Z
dc.identifierJC13NC22
dc.identifierhttp://repositorio.inprf.gob.mx/handle/123456789/7627
dc.identifierhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603095/
dc.identifierhttps://doi.org/10.3389/fendo.2019.00401
dc.identifierSuiza
dc.identifierInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier1664-2392
dc.identifier10.3389/fendo.2019.00401
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7804902
dc.descriptionCentral and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate food intake. TH concentrations are regulated by the hypothalamus-pituitary-thyroid (HPT) axis, and by transport and metabolism in blood and target tissues. In mammals, hypophysiotropic thyrotropin-releasing hormone (TRH) neurons of the paraventricular nucleus of the hypothalamus integrate energy-related information. They project to the external zone of the median eminence (ME), a brain circumventricular organ rich in neuron terminal varicosities and buttons, tanycytes, other glial cells and capillaries. These capillary vessels form a portal system that links the base of the hypothalamus with the anterior pituitary. Tanycytes of the medio-basal hypothalamus express a repertoire of proteins involved in transport, sensing, and metabolism of TH; among them is type 2 deiodinase, a source of 3,3′,5-triiodo-L-thyronine necessary for negative feedback on TRH neurons. Tanycytes subtypes are distinguished by position and phenotype. The end-feet of β2-tanycytes intermingle with TRH varicosities and terminals in the external layer of the ME and terminate close to the ME capillaries. Besides type 2 deiodinase, β2-tanycytes express the TRH-degrading ectoenzyme (TRH-DE); this enzyme likely controls the amount of TRH entering portal vessels. TRH-DE is rapidly upregulated by TH, contributing to TH negative feedback on HPT axis. Alterations in energy balance also regulate the expression and activity of TRH-DE in the ME, making β2-tanycytes a hub for energy-related regulation of HPT axis activity. β2-tanycytes also express TRH-R1, which mediates positive effects of TRH on TRH-DE activity and the size of β2-tanycyte end-feet contacts with the basal lamina adjacent to ME capillaries. These end-feet associations with ME capillaries, and TRH-DE activity, appear to coordinately control HPT axis activity. Thus, down-stream of neuronal control of TRH release by action potentials arrival in the external layer of the median eminence, imbricated intercellular processes may coordinate the flux of TRH into the portal capillaries. In conclusion, β2-tanycytes appear as a critical cellular element for the somatic and post-secretory control of TRH flux into portal vessels, and HPT axis regulation in mammals.
dc.formatPDF
dc.languageeng
dc.publisherFrontiers Research Foundation
dc.relation10:401
dc.relationFRONT ENDOCRINOL
dc.relationFrontiers in Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleTanycytes and the control of thyrotropin-releasing hormone flux into portal capillaries
dc.typeinfo:eu-repo/semantics/article


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