ArtículoAbstract Pathogenic microorganisms, including bacteria, are becoming resistant to most existing drugs, which increases the failure of pharmacologic treatment. Therefore, new nanomaterials were studied to spearhead improvement against the same resistant pathogenic bacteria. This has increased the mortality in the world population, principally in under-developed countries. Moreover, recently there has been research to find new drug formulations to kill the most dangerous microorganisms, such as bacteria cells which should avoid the spread of disease. Therefore, lately, investigations have been focusing on nanomaterials because they can exhibit the capacity to show an antibacterial effect. These studies have been trying oriented in their ability to produce an improvement to get antibacterial damage against the same pathogenic bacteria resistance. However, there are many problems with the use of nanoparticles. One of them is understanding how they act against bacteria, "their mechanism(s) action" to induce reduction or even kill the bacterial strains. Therefore, it is essential to understand the specific mechanism(s) of each nanomaterial used to observe the interaction between bacteria cells and nanoparticles. In addition, since nanoparticles can be functionalized with different antibacterial drugs, it is necessary to consider and distinguish the antibacterial activity of the nanoparticles from the antibacterial activity of the drugs to avoid confusion about how the nanoparticles work. Knowledge of these differences can help better understand the applications of the primary nanoparticles (i.e., Ag, Au, CuO, ZnO, and TiO2, among others) described in detail in this review which are toxic against various bacterial strains.