ArtículoEfficacy and safety of spectinomycin-lincomycin added to the starter feed formula for piglets at weaning plus a multivitamin in the drinking wáter for three weeks after weaned piglets was studied. Four groups were used. Groups 1, 2 and 3 development and growth was as expected. Group 2 shows a slight increase in weight, which although not significant, allows postulating that the combination of Spectinomycin-Lyncomycin and polyvitamins can be considered as EFFECTIVE AND SAFE combination to be used in weaned piglets. The control group development was slightly lower, although not significant, the weight of the control group can be considered as a cause of an environmental factor of the intensive exploitation in which the study was developed. Since they were exposed to the presence of endemic infections, a situation that Lincomycin - Spectinomycin have a recognized efficacy to prevent enteropathies. It was concluded that the profilactic and methahylactic use of spectinomycin-Lincomycin in feed plus a polivitamin formulation in drinking wáter is highly recomended.