Prolactin and Prolactin Receptor Expression In Cervical Intraepithelial Neoplasia and Cancer

dc.creatorLópez Pulido, Edgar Iván
dc.creatorAscencio Cedillo, Rafael
dc.creatorPereira Suárez, Ana Laura
dc.creatorMuñoz Valle, José Francisco
dc.creatorVillegas Sepúlveda, Nicolás
dc.creatorDel Toro Arreola, Susana
dc.creatorEstrada Chávez, Ciro
dc.creatorDaneri Navarro, Adrian
dc.creatorFranco Topete, Ramón
dc.creatorPérez Montiel, Delia
dc.creatorGarcía Carrancá, Alejandro
dc.date2015-03-17T17:01:02Z
dc.date2015-03-17T17:01:02Z
dc.date2014
dc.date.accessioned2023-07-21T21:38:21Z
dc.date.available2023-07-21T21:38:21Z
dc.identifierAscencio-Cedillo, R., López-Pulido, E. I., Muñoz-Valle, J. F., Villegas-Sepúlveda, N., Del Toro-Arreola, S., Estrada-Chávez, C., Pereira-Suárez, A. L. (2014). Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer. Pathology Oncology Research. doi:10.1007/s12253-014-9814-6
dc.identifier1532-2807
dc.identifierhttp://148.202.112.41:8080/jspui/handle/123456789/174
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7751900
dc.descriptionProlactin receptor (PRLR) overexpression could play a role in tumorigenesis. The aim of this study was to determine prolactin (PRL) and PRLR expression in biopsies from patients with precursor lesions and uterine cervical cancer. PRLR expression was analyzed in 63 paraffin-embedded biopsies of uterine cervical tissue. In total, eleven low-grade squamous intraepithelial lesions (LSIL), 23 high-grade squamous intraepithelial lesions (HSIL), 21 uterine cervical cancers (UCC) and 8 normal epithelium (NE) were examined using immunoperoxidase staining and Western blot analysis. Additionally, PRL expression was identified in human cervical cancer serum and tissues. The PRLR expression was found to be significantly increased in cervical cancer in comparison with normal tissue and precursor lesions (P < 0.0003). The presence of the long isoform of the PRLR was observed only in cervical cancer tissues. Serum PRL levels were normal in all samples and local prolactin expression was similar in precursor lesions and cervical cancer by Western blot analysis. Our data suggest a possible role for PRLR in the progression of cervical cancer.
dc.languageen
dc.publisherPathology & Oncology Research
dc.subjectcervical cancer
dc.subjectexpression
dc.subjectprolactin
dc.subjectprolactin receptor
dc.titleProlactin and Prolactin Receptor Expression In Cervical Intraepithelial Neoplasia and Cancer
dc.typeArticle


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