Modification of Ceiba pentandra cellulose for drug release applications

dc.creatorSILVIA ARGELIA PERAZA KU
dc.creatorJOSE MANUEL CERVANTES UC
dc.creatorBeatriz Escobar Morales
dc.creatorJorge Alonso Uribe Calderón
dc.date2020
dc.date.accessioned2023-07-21T19:19:27Z
dc.date.available2023-07-21T19:19:27Z
dc.identifierhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/1896
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7737448
dc.descriptionTubular fibers (raw and wax-free) from Ceiba pentandra (CP) were cross-linked with butane-1,2,3,4-tetracarboxylic acid (BTCA) at different concentrations to obtain a porous biodegradable medium for drug release applications. Chlorhexidine diacetate (CHX) was added to the cross-linked fibers for drug release studies. The Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy results indicated that the cross-linked fibers with a 5:1 fiber:BTCA ratio presented the higher cross-linking density. CHX was added at different concentrations (8% and 16% wt/wt); the elemental analysis indicated that CHX was loaded up to 7.99 wt%. In vitro studies showed a burst release of CHX within the first 3 h. CHX release kinetics was described using several models, with the Korsmeyer–Peppas equation, which adjusted better to the experimental data. The results indicated that the CP fibers are a feasible material for drug release applications.
dc.formatapplication/pdf
dc.languageeng
dc.relationinfo:eu-repo/semantics/datasetDOI/10.1515/epoly-2020-0025
dc.relationinfo:eu-repo/semantics/altIdentifier/DOI/10.1515/epoly-2020-0025
dc.relationcitation:Peraza-Ku, S. A., Cervantes-Uc, J. M., Escobar-Morales, B., & Uribe-Calderon, J. A. (2020). Modification of Ceiba pentandra cellulose for drug release applications. e-Polymers, 20(1), 194-202.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcee-Polymers, 20(1), 194-202, 2020
dc.subjectinfo:eu-repo/classification/Autores/CEIBA PENTANDRA
dc.subjectinfo:eu-repo/classification/Autores/CHLORHEXIDINE DIACETATE
dc.subjectinfo:eu-repo/classification/Autores/CELLULOSE CROSS-LINKING
dc.subjectinfo:eu-repo/classification/Autores/DRUG RELEASE
dc.subjectinfo:eu-repo/classification/cti/7
dc.subjectinfo:eu-repo/classification/cti/33
dc.subjectinfo:eu-repo/classification/cti/3312
dc.subjectinfo:eu-repo/classification/cti/331209
dc.subjectinfo:eu-repo/classification/cti/331209
dc.titleModification of Ceiba pentandra cellulose for drug release applications
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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