Preparation and characterization of electrospun fibrous scaffolds of either PVA or PVP for fast release of sildenafil citrate

dc.creatorERICK JOSE TORRES MARTINEZ
dc.creatorRicardo Vera Graziano
dc.creatorJOSE MANUEL CERVANTES UC
dc.creatorNINA BOGDANCHIKOVA
dc.creatorAMELIA OLIVAS SARABIA
dc.creatorRICARDO VALDEZ CASTRO
dc.creatorARACELY SERRANO MEDINA
dc.creatorANA LETICIA IGLESIAS
dc.creatorGRACIELA LIZETH PEREZ GONZALEZ
dc.creatorJOSE MANUEL CORNEJO BRAVO
dc.creatorLUIS JESUS VILLARREAL GOMEZ
dc.date2020
dc.date.accessioned2023-07-21T19:19:20Z
dc.date.available2023-07-21T19:19:20Z
dc.identifierhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/1841
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7737393
dc.descriptionSildenafil citrate (SC) has proved to be an effective and inexpensive drug for the treatment of pulmonary arterial hypertension (PAH). This study aims to synthesize electrospun, submicron fiber scaffolds of poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) loaded with SC for fast drug dissolution and its potential use in the treatment of PAH. These fiber scaffolds were prepared through the electrospinning technique. The chemical composition of the nanofibers was analyzed by Fourier transform infrared spectroscopy. Thermal stability was studied by thermogravimetric analysis and polymeric transitions by differential scattering calorimetry. Surface analysis of the nanofibers was studied by field emission scanning electron microscopy. The wetting and dissolution time of the scaffolds and drug release rate were studied as well. The drug-loaded PVP fibers showed better quality regarding size and homogeneity compared to drug-loaded PVA fibers. These fibers encapsulated approximately 2.5 mg/cm2 of the drug and achieved immediate controlled released rate, which is encouraging for further studies leading to an alternative treatment of PAH in children.
dc.formatapplication/pdf
dc.languageeng
dc.relationinfo:eu-repo/semantics/datasetDOI/10.1515/epoly-2020-0070
dc.relationcitation:Torres-Martínez, E. J., Vera-Graziano, R., Cervantes-Uc, J. M., Bogdanchikova, N., Olivas-Sarabia, A., Valdez-Castro, R., ... & Villarreal-Gómez, L. J. (2020). Preparation and characterization of electrospun fibrous scaffolds of either PVA or PVP for fast release of sildenafil citrate. e-Polymers, 20(1), 746-758.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcee-Polymers, 20(1), 746-758.
dc.subjectinfo:eu-repo/classification/Autores/FIBROUS SCAFFOLDS
dc.subjectinfo:eu-repo/classification/Autores/ELECTROSPINNING
dc.subjectinfo:eu-repo/classification/Autores/SILDENAFIL CITRATE
dc.subjectinfo:eu-repo/classification/Autores/POLY(VINYL ALCOHOL)
dc.subjectinfo:eu-repo/classification/Autores/POLY(VINYL PYRROLIDONE)
dc.subjectinfo:eu-repo/classification/cti/7
dc.subjectinfo:eu-repo/classification/cti/33
dc.subjectinfo:eu-repo/classification/cti/3312
dc.subjectinfo:eu-repo/classification/cti/331208
dc.subjectinfo:eu-repo/classification/cti/331208
dc.titlePreparation and characterization of electrospun fibrous scaffolds of either PVA or PVP for fast release of sildenafil citrate
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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