The main objective of this review is to update the current knowledge on species of Dorstenia genus. Previous review was published in 2000. This genus includes 117 accepted named species, from which metabolites with a great variety of structures are found. In the last fifteen years, a blooming has occurred in the research of the genus, with more than 60 original research papers on the chemistry and pharmacology of many species, being one of the main reasons to this thriving the generalized use of Dorstenia species in the traditional medicine around the world.