A synopsis of Mesoamerican Jacquinia (Theophrastaceae) species with white, yellowish, or cream-colored flowers is presented. A key for their identification is provided. All of these species are restricted to northern Mesoamerica. Among these taxa Jacquinia sak-lol Carnevali, Hernandez Aguilar & Tapia-Muñoz, from the state of Quintana Roo in the Mexican Yucatán Peninsula, is proposed as new. The new entity is described and illustrated. The proposed novelty is related to Jacquinia paludícola Standley, but it is a shrub and features smaller, more coriaceous leaves with a revolute margin and larger flowers.