In this paper the impact behavior of a laminated Ultra High Molecular Weight Polyethylene (UHMWPE), was analyzed at medium velocity impacts. The aim of this study focused on the influence on the ballistic limit of four layered laminate with three fiber configurations: [0°/0°/0°/0°], [0°/90°/0°/90°], and [+45°/-45°/0°/90°]. These three configurations were tested under multiple impacts intended to maximize the information obtained per sample tested at impact. The results show a discrete increase in the ballistic limit in the configuration [0°/90°/0°/90°], compared to [0°/0°/0°/0°] configuration, whilst on the other hand, the quasi-isotropic configuration showed significant reduction of energy absorption.