Blumenol A (1), blumenol B (2) and loliolide (3), together with the ubiquitous β-sitosterol, α-amyrin and β-amyrin, were isolated from the organic extract of the leaves of Heliotropium angiospermum. Structural elucidation of the metabolites was carried out by analysis of their spectroscopic data and/or by comparison with those reported in the literature.