"This dissertation is organized into five chapters. Chapter one corresponds to an introduction, which provides a brief explanation about the Raman spectroscopic technique, the use of CdTe for biomedical applications, the cellular uptake processes and finally the uses of SERS powdered substrates for tissue diagnosis. Chapter two explains synthesis and characterization of thioglycolic acid capped CdTe quantum dots (TGA@CdTe QDs), naked anisotropic gold nanoparticles (AuNPs) and Au/SiO2 powder. Chapter three describes the uptake, internalization and interaction of TGA@CdTe QDs and AuNPs with Haematococcus Pluvialis algae cells and human oral epithelial cells. In chapter four a systematic study of the SERS activity of Au/SiO2 powder and AuNPs for tissue diagnosis is presented and discussed. Finally, the dissertation is summarized in chapter five with the possible future works in SERS and cellular uptake for biomedical applications."