Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors

dc.creatorPeinetti, Ana S.
dc.creatorCeretti, Helena
dc.creatorMizrahi, Martín Daniel
dc.creatorGonzález, Graciela A.
dc.creatorRamírez, Silvana A.
dc.creatorRequejo, Félix Gregorio
dc.creatorMontserrat, Javier M.
dc.creatorBattaglini, Fernando
dc.date2015
dc.date2022-02-15T19:17:35Z
dc.date.accessioned2023-07-15T05:32:23Z
dc.date.available2023-07-15T05:32:23Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/131123
dc.identifierissn:2040-3372
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7473703
dc.descriptionA controlled architecture of nanoelectrodes, of a similar size to small molecule-binding aptamers, is synthesized inside nanoporous alumina. Gold nanoparticles with a controlled size (about 2 nm) are electrogenerated in the alumina cavities, showing a fast electron transfer process toward ferrocyanide. These uncapped nanoparticles are easily modified with a thiol-containing aptamer for label-free detection of adenosine monophosphate by electrochemical impedance spectroscopy. Our results show that the use of a limited electrical conducting surface inside an insulating environment can be very sensitive to conformational changes, introducing a new approach to the detection of small molecules, exemplified here by the direct and selective detection of adenosine monophosphate at the nanomolar scale.
dc.descriptionInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectQuímica
dc.subjectGold nanoparticles
dc.subjectDetection of small molecules
dc.titleConfined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
dc.typeArticulo
dc.typePreprint


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