| dc.creator | Rudzinski, Marcelo | |
| dc.creator | Pardini, Lais Luján | |
| dc.creator | Bernstein, Mariana | |
| dc.creator | Moré, Gastón Andrés | |
| dc.creator | Khoury, Marina | |
| dc.creator | Duarte, Silvana Carolina | |
| dc.creator | Argüelles, Carina Francisca | |
| dc.creator | Reina, Silvia | |
| dc.creator | Oubiña, Jose Raul | |
| dc.date | 2020-09 | |
| dc.date | 2022-11-16T17:18:46Z | |
| dc.date.accessioned | 2023-07-15T05:03:37Z | |
| dc.date.available | 2023-07-15T05:03:37Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/145951 | |
| dc.identifier | issn:1476-1645 | |
| dc.identifier | issn:0002-9637 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7471932 | |
| dc.description | Peripheral blood mononuclear cells (PBMC) from patients with ocular toxoplasmosis were challenged with total antigens from Toxoplasma gondii lysate (TATL) in a cytokine release assay (CRA), run during the inactive period of the disease. Increased interferon gamma (IFN-γ) levels were detected after PBMC stimulation with either ME49 reference strain (P = 0.0015) or local TgCkAr-11-9 isolate (P = 0.0012), as compared with those recorded under basal conditions. TATL from TgCkAr11-9 isolate induced a higher release of IFN-γ than ME49 strain in CRA from all tested patients (P = 0.02). The median value of IFN-γ release on TgCkAr-11-9 stimulation (26.03 pg/mL) allowed the classification of patients into high- or low-/non-IFN-γ releasers. Clinical correlations were established with both groups. The results obtained in this study suggest the need to include local strains when performing CRA with TATL. | |
| dc.description | Facultad de Ciencias Veterinarias | |
| dc.format | application/pdf | |
| dc.format | 2239-2243 | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
| dc.subject | Biología | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Ocular toxoplasmosis | |
| dc.subject | Cytokine release | |
| dc.title | Interferon-γ and IL-10 release assay for patients with ocular toxoplasmosis | |
| dc.type | Articulo | |
| dc.type | Articulo | |
