Articulo
The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
Registro en:
issn:0014-4754
issn:1420-9071
issn:1420-682x
Autor
Vittone, Leticia Beatriz
Chiappe, Liliana Eusebia
Argel, María Isabel
Cingolani, Horacio Eugenio
Chiappe de Cingolani, Gladys Ethel
Institución
Resumen
Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats. Centro de Investigaciones Cardiovasculares