Libro
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
Registro en:
issn:1389-1774
isbn:978-1-4615-0347-7
Autor
Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
Institución
Resumen
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in intracellular Na<sup>+</sup> concentration ([Na<sup>+</sup>]<sub>i</sub>), and the increase in the Ca<sup>2+</sup> transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912. Facultad de Ciencias Médicas