Articulo
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
Registro en:
issn:1572-8773
issn:0966-0844
Autor
Urquiza, Nora M.
Manca, Silvia G.
Moyano, María Alejandra
Dellmans, Raquel Arrieta
Lezama, Luis
Rojo, Teófilo
Naso, Luciana Gissella
Williams, Patricia Ana María
Ferrer, Evelina Gloria
Institución
Resumen
Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated. Centro de Química Inorgánica