Articulo
Glutathione-complexed iron–sulfur clusters: reaction intermediates and evidence for a template effect promoting assembly and stability
Registro en:
issn:1364-548X
issn:1359-7345
Autor
Qi, Wenbin
Li, Jingwei
Chain, Cecilia Yamil
Pasquevich, Gustavo Alberto
Pasquevich, Alberto Felipe
Cowan, J. A.
Institución
Resumen
Assembly and stabilization of a glutathione-complexed [2Fe–2S] cluster is promoted by aggregation of glutathione. The cluster core selects the tetramer species from a collection of equilibrating solution aggregate species, and in turn the core is stabilized toward hydrolytic degradation. Studies of glutathione derivatives, in combination with mass spectrometric and Mossbauer investigations provide insight on reaction intermediates during formation of [2Fe–2S](GS)₄²⁻. Facultad de Ciencias Exactas