This is comparative study of <i>Ilex paraguariensis</i> St. Hil. var. <i>paraguariensis</i> Loes., and cogeneric Argentine adulterants: <i>I. dumosa</i> Reissek var. <i>dumosa</i> Reissek, <i>I. dumosa</i> var. <i>guaranina</i> Loes., <i>I. brevicuspis</i> Reissek, <i>I. theezans</i> Reissek and <i>I. argentina</i> Lillo. The anatomy and quantitative micrographic parameters (proportional magnitudes, stomata index and palisade ratio) of these leaves was studied to the establish standards in agreement with the WHO for the vegetables drugs. A micrographic parameters table is presented for control quality of the raw material, fragmentary or powdered.Facultad de Ciencias ExactasLaboratorio de Referencia de Análisis Micrográficos de Plantas Medicinales, Alimenticias y Tóxicas