dc.creatorFederico, Marilén
dc.creatorValverde, Carlos Alfredo
dc.creatorMattiazzi, Alicia Ramona
dc.creatorPalomeque, Julieta
dc.date2020
dc.date2020-10-29T16:21:13Z
dc.date.accessioned2023-07-14T22:45:02Z
dc.date.available2023-07-14T22:45:02Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/107960
dc.identifierhttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6989610&blobtype=pdf
dc.identifierhttps://www.frontiersin.org/articles/10.3389/fphys.2019.01630/full
dc.identifierissn:1664-042X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7448064
dc.descriptionThe present review focusses on the regulation and interplay of cardiac SR Ca<sup>2+</sup> handling proteins involved in SR Ca<sup>2+</sup> uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca<sup>2+</sup> reuptake and release. The review then discusses how disruption of this balance alters SR Ca<sup>2+</sup> handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.
dc.descriptionFacultad de Ciencias Médicas
dc.descriptionCentro de Investigaciones Cardiovasculares
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)
dc.subjectMedicina
dc.subjectsarcoplasmic reticulum Ca2+-ATPase
dc.subjectryanodine receptor 2
dc.subjectarrhythimas
dc.subjectphospholamban
dc.subjectApoptosis
dc.subjectdiabetic myocardiopathy
dc.subjectisquemia-reperfusión
dc.titleUnbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
dc.typeArticulo
dc.typeArticulo


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