Articulo
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
Registro en:
issn:0974-7435
Autor
León, Ignacio Esteban
Etcheverry, Susana Beatriz
Baran, Enrique José
Institución
Resumen
The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 µM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]·3H<sub>2</sub>O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)]·1.5H<sub>2</sub>O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized. Facultad de Ciencias Exactas Centro de Química Inorgánica