Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovirRemtricitabine/lamivudineRefavirenz administered on a multiple tablet therapy

Abstract

Background: Persistent high risk HPV infection can lead to cervical cancer, the second most common malignant tumor in women worldwide. NK cells play a crucial role against tumors and virus-infected cells through a fine balance between activating and inhibitory receptors. Expression of triggering receptors NKp30, NKp44, NKp46 and NKG2D on NK cells correlates with cytolytic activity against tumor cells, but these receptors have not been studied in cervical cancer and precursor lesions. The aim of the present work was to study NKp30, NKp46, NKG2D, NKp80 and 2B4 expression in NK cells from patients with cervical cancer and precursor lesions, in the context of HPV infection. Methods: NKp30, NKp46, NKG2D, NKp80 and 2B4 expression was analyzed by flow cytometry on NK cells from 59 patients with cervical cancer and squamous intraepithelial lesions. NK cell cytotoxicity was evaluated in a 4 hour CFSE/7-AAD flow cytometry assay. HPV types were identified by PCR assays. Results: We report here for the first time that NK cell-activating receptors NKp30 and NKp46 are significantly down-regulated in cervical cancer and high grade squamous intraepithelial lesion (HGSIL) patients. NCRs down-regulation correlated with low cytolytic activity, HPV-16 infection and clinical stage. NKG2D was also down-regulated in cervical cancer patients. Conclusion: Our results suggest that NKp30, NKp46 and NKG2D down-regulation represent an evasion mechanism associated to low NK cell activity, HPV-16 infection and cervical cancer progression. " 2009 García-Iglesias et al; licensee BioMed Central Ltd.",,,,,,"10.1186/1471-2407-9-186",,,"http://hdl.handle.net/20.500.12104/42608","http://www.scopus.com/inward/record.url?eid=2-s2.0-67650267743&partnerID=40&md5=f6766e4d4e204e9b006a91eda242893c

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19531227",,,,,,,,"BMC Cancer",,"186",,"9",,"Scopus

WOS

MEDLINE",,,,"Index Medicus;Adult;Antigens, CD/bi [Biosynthesis];Carcinoma, Squamous Cell/im [Immunology];Carcinoma, Squamous Cell/vi [Virology];Cervical Intraepithelial Neoplasia/im [Immunology];Cervical Intraepithelial Neoplasia/vi [Virology];Cytotoxicity, Immunologic;Down-Regulation;Female;Flow Cytometry;Human papillomavirus 16/im [Immunology];Human papillomavirus 16/ip [Isolation & Purification];Humans;K562 Cells;Killer Cells, Natural/im [Immunology];Lectins, C-Type;Middle Aged;NK Cell Lectin-Like Receptor Subfamily K/bi [Biosynthesis];Natural Cytotoxicity Triggering Receptor 1/bi [Biosynthesis];Natural Cytotoxicity Triggering Receptor 3/bi [Biosynthesis];Papillomavirus Infections/im [Immunology];Papillomavirus Infections/vi [Virology];Receptors, Immunologic/bi [Biosynthesis];Receptors, Natural Killer Cell/bi [Biosynthesis];Uterine Cervical Neoplasms/im [Immunology];Uterine Cervical Neoplasms/vi [Virology]",,,,,,,,"Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions",,"Article" "38369","123456789/35008",,,"Ramírez Saiz, J. M.",,"1993",,,,,,,,,,"0186-7210",,"http://hdl.handle.net/20.500.12104/36590",,"Español",,,,"2",,"Estudios demográficos y urbanos",,"477-481",,"8",,"CLASE",,,,,,,,"Sociología urbana",,"Luhmann n. Sociologia del riesgo. Universidad iberoamericana - universidad de guadalajara, 1992",,,,"journalArticle", "38370","123456789/35008",,"Arias, Patricia Universidad de Guadalajara",,"Arias, Patricia Universidad de Guadalajara",,"2006",,,,,,,,,,"1405-9274","http://hdl.handle.net/20.500.12104/36591",,,"Español",,,,"21",,"Revista de Antropología Social",,"177-186",,,,"CLASE",,,,,,,,"Historiografía",,,,"Luis González. Microhistoria e historia regional",,"journalArticle" "44388","123456789/35008","Feria-Velasco, A., Depto. Biología Celular Y Molecular, Centro Universitario de Ciencias Biológicas Y Agropecuarias (CUCBA), Universidad de Guadalajara (U de G), Km. 15.5 Carr. Guad.-Nogales, 45100 Las Agujas Nextipac, Zapopan, Jal., Mexico; Mena-Munguía, S., Depto. Producción Agrícola, CUCBA, U. de G., Guadalajara, Jal., Mexico; Cárabez-Torres, J., Depto. Producción Animal, CUCBA, U de G, Guadalajara, Jal., Mexico; Gómez-Medrano, A., Depto. Producción Agrícola, CUCBA, U. de G., Guadalajara, Jal., Mexico; Recéndiz-Hurtado, F., Depto. Producción Agrícola, CUCBA, U. de G., Guadalajara, Jal., Mexico; Orozco-Suárez, S., Unidad de Investigación Médica en Enfermedades Neurológicas, H. Especialidades, Institituto Mexicano del Seguro Social (IMSS), Mexico, DF, Mexico; Beas-Zárate, C., Depto. Biología Celular Y Molecular, Centro Universitario de Ciencias Biológicas Y Agropecuarias (CUCBA), Universidad de Guadalajara (U de G), Km. 15.5 Carr. Guad.-Nogales, 45100 Las Agujas Nextipac, Zapopan, Jal., Mexico, División de Neurociencias, Centro de Investigación Biomédica de Occidente, IMSS, Guadalajara, Jal., Mexico

Beas-Zárate, Carlos., Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias",,"Feria-Velasco, A.

Mena-Munguia, S.

Carabez-Torres, J.

Gomez-Medrano, A.

Recendiz-Hurtado, F.

Orozco-Suarez, S.

Beas-Zárate, Carlos",,"2008",,"Tryptophan (TRY) is the precursor for serotonin (5-HT) synthesis. Common maize has low protein content with low concentration of TRY and lysine. A diet based on two strains of corn differing in their TRY content were given to adult female rats, prior mating, during pregnancy and lactation. Same diets were offered to their male offspring after weaning until reaching 60-days old. The pattern and severity of the convulsive phenomenon induced by monosodium glutamate (MSG) in a well established model of Status epilepticus were evaluated in comparison with data from animals of two control groups: (a) rats fed a hypoproteic (8% protein) diet, and (b) rats fed a normal Purina chow diet (23% protein). Significant increased susceptibility to convulsions was observed in both groups of rats fed the corn-based diets. However, the animals fed the common corn-based diet (8-9% protein; 0.058% TRY) showed a higher susceptibility to convulsions than what was registered in animals fed a Quality Protein Maize (QPM)-based diet (8-9% protein; 0.1% TRY). It is concluded that low TRY concentration in the diet during development, produces lower rate of brain 5-HT synthesis, affecting development and maturation of GABAergic inhibitory cortical interneurons, with alteration of cortical excitability, contributing in part, to the increased susceptibility to convulsions, as shown in the experiments here reported. © 2008 Springer Science+Business Media, LLC.",,,,,,"10.1007/s11064-008-9613-0",,,,"http://www.scopus.com/inward/record.url?eid=2-s2.0-46249118317&partnerID=40&md5=0a4bb9f55afedcd2793d8363478e879f

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=18273702

http://hdl.handle.net/20.500.12104/42609",,,,,,"8",,"Neurochemical Research",,"1484

1491",,"33",,"Scopus

WOS

MEDLINE",,,,"Index Medicus;Animals;Diet;Dietary Proteins;Disease Susceptibility;Female;Food Additives/pd [Pharmacology];Humans;Lysine/me [Metabolism];Male;Pregnancy;Proteins/me [Metabolism];Rats;Rats, Wistar;Reaction Time;Seizures/ci [Chemically Induced];Seizures/me [Metabolism];Seizures/pp [Physiopathology];Sodium Glutamate/pd [Pharmacology];Tryptophan/me [Metabolism];Zea mays/ch [Chemistry]",,"Convulsions; Corn-diet; Hyperexcitability; Malnourished rats; Monosodium glutamate; Tryptophan",,,,"Low tryptophan and protein in the diet during development increase the susceptibility to convulsions in adult rats",,,,"Article", "38371","123456789/35008",,,,"Tapia Curiel, Amparo",,"2001",,,,,,,,,,"0187-7674","http://hdl.handle.net/20.500.12104/36592",,,"Español",,,,"76",,"Confines de relaciones internacionales y ciencia política",,"40-45",,"13",,"CLASE",,,,,,,,"Economía del trabajo",,,,"Magnitud del trabajo infantil",,"journalArticle" "38373","123456789/35008",,,"Ribes Iñesta, Emilio",,"1994",,,,,,,,,,"0185-4534",,"http://hdl.handle.net/20.500.12104/36594",,"Español",,,,"2",,"Revista mexicana de análisis de la conducta",,"227-239",,"20",,"CLASE",,,,"Historia y filosofía de la psicología",,,,,,"¿Qué significa ser interconductista?","¿Qué significa ser interconductista?",,,"journalArticle", "44389","123456789/35008",,"Rodríguez, J.L., Depto. de Quim. e Ing. Quimica, Universidad Nacional del Sur, Avda. Alem 1253, 8000 Bahía Blanca, Bs. As., Argentina; Schulz, P.C., Depto. de Quim. e Ing. Quimica, Universidad Nacional del Sur, Avda. Alem 1253, 8000 Bahía Blanca, Bs. As., Argentina; Puig, J.E., Depto. de Ing. Química, Ctr. Univ. de Cie. e Ingenierias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico",,"Rodriguez, J.L.

Schulz, P.C.

Puig, J.E.",,"1999",,"The behaviors of low-concentration aqueous solutions of 10-undecenoic acid and its sodium salt were studied by several techniques. The acid does not have a critical micelle concentration, but gives an emulsion of very small droplets at (0.8-1) x 10-4 mol dm-3. The emulsion was clearly visible by eye at 0.002 mol dm-3. The sodium salt has a stepwise aggregation process, giving premicellar aggregates at 0.023 ± 0.008 mol dm-3, which grow to form micelles at 0.117 ± 0.007 mol dm-3. The compositions of the solution and the micelles were also studied.",,,,,,"10.1007/s003960050492",,,"http://hdl.handle.net/20.500.12104/42610","http://www.scopus.com/inward/record.url?eid=2-s2.0-0345476319&partnerID=40&md5=b64e3ab893e96128cc90d2a805703ca1",,,,,,"11",,"Colloid and Polymer Science",,"1072

1078",,"277",,"Scopus

WOS",,,,,,"Critical micelle concentration; Micelles; Polymerizable surfactant; Sodium undecenoate; Undecenoic acid",,,,,,"Low-concentration aqueous solutions of undecenoic acid and sodium undecenoate",,"Article" "38372","123456789/35008","Ramírez, Juan Carlos Universidad de Guadalajara",,"Ramírez, Juan Carlos Universidad de Guadalajara",,"1996",,,,,,,,,,"1405-3098",,"http://hdl.handle.net/20.500.12104/36593",,"Español",,,,"10",,"Géneros",,"82-83",,"4",,"CLASE",,,,,,,,"Sociología de la mujer",,"Magnitud y trascendencia de la violencia doméstica contra la mujer",,,,"journalArticle", "38374","123456789/35008",,,,"Acosta Silva, Adrián",,"2000",,,,,,,,,,"0251-3552","http://hdl.handle.net/20.500.12104/36595",,,"Español",,,,"170",,"Nueva sociedad",,"51-56",,,,"CLASE",,,,,,,,"Gobierno",,,"Mann, Michael. The Sources of Social Power. The Rise of Classes and Nation-States, 1760-1914, Cambridge","Mann, Michael. The Sources of Social Power. The Rise of Classes and Nation-States, 1760-1914, Cambridge: Cambridge University Press, 1993, 826 p.",,"journalArticle" "38375","123456789/35008",,"Venegas Herrera, Amparo del Carmen Universidad de Guadalajara",,"Venegas Herrera, Amparo del Carmen Universidad de Guadalajara",,"2006",,,,,,,,,,"0187-7674","http://hdl.handle.net/20.500.12104/36596",,,"Español",,,,"96",,"Confines de relaciones internacionales y ciencia política",,"mar-15",,"18",,"CLASE",,,,,,,,"Condiciones económicas",,,,"Mapa de la pobreza urbana en la Zona Metropolitana de Guadalajara y definición de las zonas marginadas para la aplicación de políticas públicas",,"journalArticle" "44390","123456789/35008",,"Cuevas, E., Department of Computational Sciences, Universidad de Guadalajara, CUCEI, Guadalajara, Jal, Mexico; Zaldivar, D., Department of Computational Sciences, Universidad de Guadalajara, CUCEI, Guadalajara, Jal, Mexico; Pérez-Cisneros, M., Department of Computational Sciences, Universidad de Guadalajara, CUCEI, Guadalajara, Jal, Mexico",,"Cuevas, E.

Zaldivar, D.

Perez-Cisneros, M.",,"2010",,"This paper shows the potential of a Lego\c{opyright}-based low-cost commercial robotic platform for learning and testing prototypes in higher education and research. The overall set-up aims to explain mobile robotic issues, including mechatronics, robotics and automatic control theory. The capabilities and limitations of Lego robots are studied within two experiments: the fi rst shows how to eliminate a number of restrictions in Lego robots using some programming alternatives; the second addresses the complex problem of multi-position control. Algorithms and their additional tools have been fully designed, applied and documented, and the results are shown throughout the paper. The platform was found to be suitable for teaching and researching key issues related to the aforementioned fi elds.",,,,,,,,,"http://hdl.handle.net/20.500.12104/42611","http://www.scopus.com/inward/record.url?eid=2-s2.0-79952492292&partnerID=40&md5=f5121ac9aaa5679a5ac07fbe26ddb254",,,,,,"2",,"International Journal of Electrical Engineering Education",,"132

150",,"47",,"Scopus",,,,,,"Mobile robotics; Robotics; Robotics learning",,,,,,"Low-cost commercial Lego\c{opyright} platform for mobile robotics",,"Article" "38377","123456789/35008","Aceves González, Francisco de Jesús Universidad de Guadalajara",,"Aceves González, Francisco de Jesús Universidad de Guadalajara",,"2005",,,,,,,,,,"0188-252X",,"http://hdl.handle.net/20.500.12104/36598",,"Español",,,,"4",,"Comunicación y sociedad",,"39-66",,,,"CLASE",,,,,,,,"Medios de comunicación masiva",,"Marketing político y rentabilidad electoral: el caso del Distrito 10 de Jalisco en las elecciones federales de 2003","Marketing político y rentabilidad electoral",,,"journalArticle", "38376","123456789/35008",,,"Ibañez, Alfonso",,"2001",,,,,,,,,,"1665-0565",,"http://hdl.handle.net/20.500.12104/36597",,"Español",,,,"22",,"Espiral. Estudios sobre estado y sociedad",,"nov-24",,"8",,"CLASE",,,,,,,,"Ideología",,"Mariategui: un marxista nietzscheano","Mariategui",,,"journalArticle", "38378","123456789/35008",,,,"Reguillo, Rossana",,"1999",,,,,,,,,,"0188-252X","http://hdl.handle.net/20.500.12104/36599",,,"Español",,,,"27",,"Comunicación y sociedad",,"247-264",,,,"CLASE",,,,,,,,"Historia y teorías de la comunicación",,,"Martín Barbero, Jesús. Pre-textos. Conversaciones sobre la comunicación y sus contextos, Cali","Martín Barbero, Jesús. Pre-textos. Conversaciones sobre la comunicación y sus contextos, Cali: Universidad del Valle, 1995",,"journalArticle" "38381","123456789/35008",,,"Reguillo, Rossana",,"1997",,,,,,,,,,"0188-252X",,"http://hdl.handle.net/20.500.12104/36602",,"Español",,,,"30",,"Comunicación y sociedad",,"127-147",,,,"CLASE",,,,,,,,"Historia y teorías de la comunicación",,"Más allá de los medios. Diez años después",,,,"journalArticle", "38379","123456789/35008",,"Valenzuela, M. Basilia Universidad de Guadalajara",,"Valenzuela, M. Basilia Universidad de Guadalajara",,"2004",,,,,,,,,,"1665-0565","http://hdl.handle.net/20.500.12104/36600",,,"Español",,,,"31",,"Espiral. Estudios sobre estado y sociedad",,"323-333",,"11",,"CLASE",,,,,,,,"Organización social",,,"Martínez Barragán, Hirineo. Límites municipales en Jalisco, México","Martínez Barragán, Hirineo. Límites municipales en Jalisco, México: Geocalli, 2003, 149 p.",,"journalArticle" "38380","123456789/35008",,"Vázquez Anderson, Annel Universidad de Guadalajara",,"Vázquez Anderson, Annel Universidad de Guadalajara",,"2004",,,,,,,,,,"0188-252X","http://hdl.handle.net/20.500.12104/36601",,,"Español",,,,"2",,"Comunicación y sociedad",,"247-273",,,,"CLASE",,,,,,,,"Historia y teorías de la comunicación",,,"Más allá de Habermas","Más allá de Habermas: la realidad de los medios de comunicación",,"journalArticle" "38382","123456789/35008",,"Ramírez Rodríguez, Juan Carlos Universidad de Guadalajara",,"Ramírez Rodríguez, Juan Carlos Universidad de Guadalajara",,"2005",,,,,,,,,,"0188-4557","http://hdl.handle.net/20.500.12104/36603",,,"Español",,,,"26",,"Estudios sociales (Hermosillo, Son.)",,"jul-25",,"13",,"CLASE",,,,,,,,"Problemas sociales",,,"Más allá de un videoclip de violencia","Más allá de un videoclip de violencia: la argamasa entre varones y mujeres",,"journalArticle" "38383","123456789/35008",,,,"Almada, Rossana",,"2001",,,,,,,,,,"1665-0565","http://hdl.handle.net/20.500.12104/36604",,,"Español",,,,"21",,"Espiral. Estudios sobre estado y sociedad",,"nov-36",,"7",,"CLASE",,,,,,,,"Asentamientos humanos",,,,"Mass media, espacio y tiempo en Todos Santos, Baja California Sur",,"journalArticle" "38384","123456789/35008",,,,"Sánchez Ruiz, Enrique E.",,"1997",,,,,,,,,,"0187-8190","http://hdl.handle.net/20.500.12104/36605",,,"Español",,,,"51",,"Revista mexicana de comunicación",,"05-sep",,"10",,"CLASE",,,,"Cine",,,,,,,"¿Se "norteamericaniza" el cine en México?","¿Se "norteamericaniza" el cine en México? Disminuye alarmantemente la producción y exhibición de las cintas nacionales",,"journalArticle" "44391","123456789/35008",,"Flores-Moreno, R., Department of Chemistry, University of Guadalajara, Blvd. Marcelino García Barragán 1421, Guadalajara Jal. C.P. 44430, Mexico; Posada, E., Department of Chemistry, Universidad Nacional de Colombia, Av. Cra. 30, 45-03 Bogotá, Colombia, Colombia; Moncada, F., Department of Chemistry, Universidad Nacional de Colombia, Av. Cra. 30, 45-03 Bogotá, Colombia, Colombia; Romero, J., Department of Chemistry, Universidad Nacional de Colombia, Av. Cra. 30, 45-03 Bogotá, Colombia, Colombia; Charry, J., Department of Chemistry, Universidad Nacional de Colombia, Av. Cra. 30, 45-03 Bogotá, Colombia, Colombia; Díaz-Tinoco, M., Department of Chemistry, University of Guadalajara, Blvd. Marcelino García Barragán 1421, Guadalajara Jal. C.P. 44430, Mexico; González, S.A., Department of Chemistry, Universidad Nacional de Colombia, Av. Cra. 30, 45-03 Bogotá, Colombia, Colombia; Aguirre, N.F., Instituto de Física Fundamental (C.S.I.C.), Serrano 123, E-28006 Madrid, Spain; Reyes, A., Department of Chemistry, Universidad Nacional de Colombia, Av. Cra. 30, 45-03 Bogotá, Colombia, Colombia",,"Flores-Moreno, R.

Posada, E.

Moncada, F.

Romero, J.

Charry, J.

Diaz-Tinoco, M.

Gonzalez, S.A.

Aguirre, N.F.

Reyes, A.",,"2014",,"LOWDIN is a computational program that implements the Any Particle Molecular Orbital (APMO) method. The current version of the code encompasses Hartree-Fock, second-order Moller-Plesset, configuration interaction, density functional, and generalized propagator theories. LOWDIN input file offers a unique flexibility, allowing users to exploit all the programs' capabilities to study systems containing any type and number of quantum species. This review provides a basic introduction to LOWDIN's key computational details and capabilities. " 2013 Wiley Periodicals, Inc. LOWDIN is a versatile computational program that implements the any particle molecular orbital (APMO) method. In the APMO framework, typical electronic structure methodologies are extended to any type of quantum particle. With the LOWDIN program, systems containing any type and number of quantum species can be studied. Copyright " 2013 Wiley Periodicals, Inc.",,,,,,"10.1002/qua.24500",,,"http://hdl.handle.net/20.500.12104/42612","http://www.scopus.com/inward/record.url?eid=2-s2.0-84888437695&partnerID=40&md5=f92dc20bad6a271e01df2f5d8117086a",,,,,,"1",,"International Journal of Quantum Chemistry",,"50

56",,"114",,"Scopus

WOS",,,,,,"APMO method; exotic molecules; isotope effects; nuclear quantum effects; propagator method",,,,,,"LOWDIN: The any particle molecular orbital code",,"Article" "38387","123456789/35008",,,"Orozco Gómez, Guillermo",,"2002",,,,,,,,,,"0120-4823",,"http://hdl.handle.net/20.500.12104/36608",,"Español",,,,"41",,"Signo y Pensamiento",,"21-33",,"21",,"CLASE",,,,,,,,"Medios de comunicación masiva",,"Mediaciones tecnológicas y des-ordenamientos comunicacionales",,,,"journalArticle", "38385","123456789/35008",,,"Mora Rosas, Manuel",,"1999",,,,,,,,,,"0188-252X",,"http://hdl.handle.net/20.500.12104/36606",,"Español",,,,"35",,"Comunicación y sociedad",,"269-274",,,,"CLASE",,,,,,,,"Historia y teorías de la comunicación",,"Mattelart, Armand. Historia de las teorías de la comunicación, Barcelona: Paidós Comunicación, 1997, 142 p.","Mattelart, Armand. Historia de las teorías de la comunicación, Barcelona",,,"journalArticle", "38386","123456789/35008",,"Avila, Ricardo Universidad de Guadalajara",,"Avila, Ricardo Universidad de Guadalajara",,"2004",,,,,,,,,,"1405-1117","http://hdl.handle.net/20.500.12104/36607",,,"Inglés",,,,"19",,"Estudios del hombre",,"105-125",,,,"CLASE",,,,,,,,"Antropología de la cultura",,,,"Meat gluttons of western Mexico",,"journalArticle" "38388","123456789/35008",,"Rivera, Horacio Universidad de Guadalajara",,"Rivera, Horacio Universidad de Guadalajara",,"2002",,,,,,,,,,"0188-5405","http://hdl.handle.net/20.500.12104/36609",,,"Español",,,,"141",,"Este país (México, D.F.)",,"88-90",,,,"CLASE",,,,,,,,"Ciencia",,,"Medicina genómica","Medicina genómica: triunfalismo avasallante",,"journalArticle" "44392","123456789/35008",,"Blanco, J.L., Hospital ClinicBarcelona, Spain; Montaner, J.S.G., BC Centre for Excellence in HIV/AIDS, St Paul's HospitalVancouver, Canada; Marconi, V.C., Emory University School of MedicineAtlanta, GA, United States; Santoro, M.M., Tor Vergata UniversityRome, Italy; Campos-Loza, A.E., Hospital Civil de Guadalajara, University of GuadalajaraMexico, United States; Shafer, R.W., Division of Infectious Diseases, Department of Medicine, Stanford University, United States; Miller, M.D., Gilead Sciences, Inc.Foster City, CA, United States; Paredes, R., IrsiCaixa Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma Barcelona, Spain; Harrigan, R., BC Centre for Excellence in HIV/AIDS, St Paul's HospitalVancouver, Canada; Nguyen, M.L., Emory University School of MedicineAtlanta, GA, United States; Perno, C.F., Antiviral Drug Monitoring Unit, INMI L SpallanzaniRome, Italy; Gonzalez-Hernandez, L.A., Hospital Civil de Guadalajara, University of GuadalajaraMexico, United States; Gatell, J.M., Hospital ClinicBarcelona, Spain",,"Blanco, J.L.

Montaner, J.S.G.

Marconi, V.C.

Santoro, M.M.

Campos-Loza, A.E.

Shafer, R.W.

Miller, M.D.

Paredes, R.

Harrigan, R.

Nguyen, M.L.

Perno, C.F.

Gonzalez-Hernandez, L.A.

Gatell, J.M.",,"2014",,"Background: Fixed-dose combination antiretroviral therapy administered as a singletablet regimen (STR) may improve virologic suppression rates. The effect of STRs on development of resistance when virologic failure occurs on STRs is not known. " 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.