The HUman MicroNucleus project on eXfoLiated buccal cells (HUMN XL): The role of life-style, host factors, occupational exposures, health status, and assay protocol

dc.contributorBonassi, S., Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Pisana, Via di Val Cannuta, Roma, Italy; Coskun, E., Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Pisana, Via di Val Cannuta, Roma, Italy, Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey; Ceppi, M., Unit of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy; Lando, C., Unit of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy; Bolognesi, C., Unit of Environmental Carcinogenesis, National Cancer Research Institute, Genoa, Italy; Burgaz, S., Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey; Holland, N., School of Public Health, University of California, Berkeley, CA, United States; Kirsh-Volders, M., Laboratory for Cell Genetics, Vrije Universiteit Brussel, Brussels, Belgium; Knasmueller, S., Institute of Cancer Research, Medical University, Vienna, Austria; Zeiger, E., Errol Zeiger Consulting, Chapel Hill, NC, United States; Carnesoltas, D., Laboratory of Clinical and Experimental Pharmacology, National Institute of Oncology and Radiobiology, 10400 Havana, Cuba; Cavallo, D., Department of Occupational Medicine, INAIL formerly ISPESL- National Institute of Occupational Safety and Prevention, 00040 Monteporzio Catone, Roma, Italy; da Silva, J., Laboratorio de Genética Toxicológica, Curso de Biologia, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil; de Andrade, V.M., Laboratory of Cellular and Molecular Biology, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina, Brazil; Demircigil, G.C., Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey; Odio, A.D., Dirección de Investigación y Desarrollo, Laboratorio de Productos Biofarmacéuticos y Químicos (LABIOFAM), La Habana, Cuba; Donmez-Altuntas, H., Laboratory of Medical Biology, Medical Faculty, Erciyes University, 38039 Kayseri, Turkey; Gattas, G., Laboratorio de Citogenética e Biologia Molecular, Departamento de Medicina Legal, ética Médica e Medicina Social e do Trabalho, Faculdade de Medicina - USP, Sao Paulo, Brazil; Giri, A., Molecular and Human Genetics Division, Division of Human Genetics and Genomics, Indian Institute of Chemical Biology, Kolkata, India; Giri, S., Laboratory of Genetic Toxicology, Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India; Gómez-Meda, B., Instituto de Biología Molecular en Medicina y Terapia Génica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340 Guadalajara, Jalisco, Mexico; Gómez-Arroyo, S., Laboratorio de Citogenética Ambiental, Centro de Ciencias de la Atmósfera, Ciudad Universitaria, Universidad Nacional Autónoma de México, 04510 Coyoacán, México City, México; Hadjidekova, V., Laboratory of Radiation Genetics, National Centre of Radiobiology and Radiation Protection, 1606 Sofia, Bulgaria; Haveric, A., Laboratory for cytogenetics and genotoxicology, Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina; Kamboj, M., Department of Oral Pathology and Microbiology, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow 226003, Uttar Pradesh, India; Kurteshi, K., Genetic Laboratory, Department of Biology, Faculty of Natural Science, University of Prishtina, Eqrem Qabej, Prishtina, Kosova, Serbia; Martino-Roth, M.G., Escola de Saúde, Departamento de Zoologia e Genética, Universidade Federal de Pelotas, Pelotas, Brazil; Montoya, R.M., Dpto. Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, 70228 Mexico City, Mexico; Nersesyan, A., Institute of Cancer Research, Medical University, Vienna, Austria, National Center of Oncology, 0052 Yerevan, Armenia; Pastor-Benito, S., Departament de Genética i de Microbiologia, Facultat de Biociències, Universitat Autónoma de Barcelona, 08193 Bellaterra, Spain; Salvadori, D.M.F., Laboratorio de Toxicogenómica and Nutrigenómica, Departamento de Patologia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, SP, Brazil; Shaposhnikova, A., Laboratory of Genetics, Kemorovo State University, 650043 Kemerovo, Russian Federation; Stopper, H., Department of Toxicology, University of Wuerzburg, D-97078 Wuerzburg, Germany; Thomas, P., CSIRO Food and Nutritional Sciences, Adelaide, SA 5000, Australia; Torres-Bugarán, O., Laboratorio de Investigación, Programa Internacional, Facultad de Medicina, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, Mexico; Yadav, A.S., Human Genetics Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra, 136119 Haryana, India; González, G.Z., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Fenech, M., CSIRO Food and Nutritional Sciences, Adelaide, SA 5000, Australia
dc.creatorBonassi, S.
dc.creatorCoskun, E.
dc.creatorCeppi, M.
dc.creatorLando, C.
dc.creatorBolognesi, C.
dc.creatorBurgaz, S.
dc.creatorHolland, N.
dc.creatorKirsh-Volders, M.
dc.creatorKnasmueller, S.
dc.creatorZeiger, E.
dc.creatorCarnesoltas, D.
dc.creatorCavallo, D.
dc.creatorda Silva, J.
dc.creatorde Andrade, V.M.
dc.creatorDemircigil, G.C.
dc.creatorOdio, A.D.
dc.creatorDonmez-Altuntas, H.
dc.creatorGattas, G.
dc.creatorGiri, A.
dc.creatorGiri, S.
dc.creatorGomez-Meda, B.
dc.creatorGomez-Arroyo, S.
dc.creatorHadjidekova, V.
dc.creatorHaveric, A.
dc.creatorKamboj, M.
dc.creatorKurteshi, K.
dc.date.accessioned2015-09-15T19:08:41Z
dc.date.accessioned2023-07-03T23:34:08Z
dc.date.available2015-09-15T19:08:41Z
dc.date.available2023-07-03T23:34:08Z
dc.date.created2015-09-15T19:08:41Z
dc.date.issued2011
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-80053592718&partnerID=40&md5=9d2627001579dcb3fe86767fe77ef624
dc.identifierhttp://hdl.handle.net/20.500.12104/45177
dc.identifier10.1016/j.mrrev.2011.06.005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7250081
dc.description.abstractThe human buccal micronucleus cytome assay (BMCyt) is one of the most widely used techniques to measure genetic damage in human population studies. Reducing protocol variability, assessing the role of confounders, and estimating a range of reference values are research priorities that will be addressed by the HUMN XL collaborative study. The HUMN XL project evaluates the impact of host factors, occupation, life-style, disease status, and protocol features on the occurrence of MN in exfoliated buccal cells. In addition, the study will provide a range of reference values for all cytome endpoints. A database of 5424 subjects with buccal MN values obtained from 30 laboratories worldwide was compiled and analyzed to investigate the influence of several conditions affecting MN frequency. Random effects models were mostly used to investigate MN predictors. The estimated spontaneous MN frequency was 0.74 (95% CI 0.52-1.05). Only staining among technical features influenced MN frequency, with an abnormal increase for non-DNA-specific stains. No effect of gender was evident, while the trend for age was highly significant (p<0.001). Most occupational exposures and a diagnosis of cancer significantly increased MN and other endpoints frequencies. MN frequency increased in heavy smoking (?40cig/day, FR=1.37; 95% CI 1.03-82) and decreased with daily fruit consumption (FR=0.68; 95% CI 0.50-0.91). The results of the HUMN XL project identified priorities for validation studies, increased the basic knowledge of the assay, and contributed to the creation of a laboratory network which in perspective may allow the evaluation of disease risk associated with MN frequency. © 2011 Elsevier B.V.
dc.relationScopus
dc.relationWOS
dc.relationMutation Research - Reviews in Mutation Research
dc.relation728
dc.relation3
dc.relation88
dc.relation97
dc.titleThe HUman MicroNucleus project on eXfoLiated buccal cells (HUMN XL): The role of life-style, host factors, occupational exposures, health status, and assay protocol
dc.typeReview


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