Article
FAS -670A>G promoter polymorphism is associated with soluble Fas levels in primary Sjögren's syndrome
Fecha
2004Registro en:
10.4238/2014.July.2.12
Autor
Pasquier, J.L.
Institución
Resumen
A previous paper introduced a model of architecture called Neuromorphic Autonomous Controller (NAC) conformed by interconnected modules, each one in charge of growing its own network of cells. The integration of all internal structures results from automatic mechanisms which, triggering elementary actions, leads to correlations learning between local states. Though concluding in the viability of this approach, aimed at performing autonomous training, adaptation and control, combinatory explosion was mentioned as the main challenge to face. Focused on reducing this side effect, this paper acquaints with some enhancements to the NAC model, including: improving internal module structure, generating an alternative representation and defining a more accurate cooperation between modules. " Springer-Verlag 2004.",,,,,,,,,"http://hdl.handle.net/20.500.12104/41435","http://www.scopus.com/inward/record.url?eid=2-s2.0-35048837564&partnerID=40&md5=54b71ccde56f5192d0cccba9a330a72b",,,,,,,,"Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",,"252 260",,"3061",,"Scopus WOS",,,,,,,,,,,,"Facing combinatory explosion in NAC networks",,"Article"
"43238","123456789/35008",,"Treviño-Talavera, B.A., Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico; Palafox-Sánchez, C.A., Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico, Department of Rheumatology, Western General Hospital, Zapopan, Jalisco, Mexico; Muñoz-Valle, J.F., Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico; Orozco-Barocio, G., Department of Rheumatology, Western General Hospital, Zapopan, Jalisco, Mexico; Navarro-Hernández, R.E., Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico; Mercado, M.V.-D., Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico; García de la Torre, I., Department of Rheumatology, Western General Hospital, Zapopan, Jalisco, Mexico; Oregon-Romero, E., Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico",,"Trevino-Talavera, B.A. Palafox-Sanchez, C.A. Munoz-Valle, J.F. Orozco-Barocio, G. Navarro-Hernandez, R.E. Mercado, M.V.-D. García de la Torre, I. Oregon-Romero, E.",,"2014",,"Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. Soluble Fas receptor (sFas) has been suggested as a Fas-mediated apoptosis blocker that could impair clonal deletion in infiltrated autoreactive cells. The FAS -670A>G promoter polymorphism has been studied in pSS. However, a relationship between FAS -670A>G promoter polymorphism and sFas levels in pSS had not been found. We examined this relationship in 77 Mexican pSS patients and 84 healthy subjects were included. Genotypes were identified by PCR-RFLP, and Fas soluble levels were quantified by ELISA. No significant differences between allele and genotype frequencies were found between these two groups. The sFas levels in the serum of pSS patients were significantly higher than in controls (9961 vs 8840 pg/mL, respectively). In addition, AA genotype carriers had significantly higher levels of sFas than GG carriers (pSS: 10,763 and 9422 pg/mL; controls: 9712 and 8305 pg/mL, respectively). An additive model analysis between genotypes (AG+GG vs AA) in both groups, demonstrated a significant association between carriers of the A allele and high sFas levels. In conclusion, carrying the double dose of A allele of FAS -670A>G polymorphism is associated with high levels of sFas in pSS, but it is not a susceptibility marker for pSS. " FUNPEC-RP.