dc.contributor | Botero Cadavid, Juan Fernando | |
dc.contributor | Garcia Sucerquia, Jorge | |
dc.contributor | Optica y Procesamiento Opto-Digital | |
dc.contributor | Patiño Jurado, Brayan de Jesús [0000-0001-7128-2525] | |
dc.contributor | García Sucerquia, Jorge Iván [0000-0003-3449-6094] | |
dc.creator | Patiño-Jurado, Brayan | |
dc.date.accessioned | 2023-05-23T14:53:40Z | |
dc.date.accessioned | 2023-06-06T23:44:23Z | |
dc.date.available | 2023-05-23T14:53:40Z | |
dc.date.available | 2023-06-06T23:44:23Z | |
dc.date.created | 2023-05-23T14:53:40Z | |
dc.date.issued | 2023 | |
dc.identifier | https://repositorio.unal.edu.co/handle/unal/83841 | |
dc.identifier | Universidad Nacional de Colombia | |
dc.identifier | Repositorio Institucional Universidad Nacional de Colombia | |
dc.identifier | https://repositorio.unal.edu.co/ | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/6651483 | |
dc.description.abstract | The undertaken research work for this thesis dissertation aims for the development of a fiber optics sensing platform, which allows for the effective detection of chemical and biological species at low concentrations. This work is presented as an alternative solution to the problem posed by a lack of new portable rapid-detection technology in Colombia for the in-situ measurement of low concentrations of certain substances such as the Bovine serum albumin or Mycobacterium tuberculosis sample or the toxic ions mercury in the drinking water. In response to the robust and rapid techniques generally require complex sample preparation procedures, expensive and bulky instruments, and professionally trained personnel, which limits their portability and making them more difficult to implement in the field for vulnerable populations in remote areas.
This thesis dissertation firstly presents the detailed review of the state of the art of problems involved in the detection and monitoring of chemical species such as mercury in water and biological species such as the Anti-BSA and Mycobacterium tuberculosis. Then, the evaluation, modeling, designing and fabrication of cost-effective optics fiber sensors based on interferometric principles is presented in order to determine the ability to functionalize these sensing structures with chemical or biological specific recognition substances. A reliable functionalization and activation protocol was studied, implemented, and evaluated in order to obtain a sensing surface on the optical fiber structures highly selective to detect the substances at low concentrations. Finally, the implementation and integration of the functionalized optical fiber sensor within a designed platform was evaluated with the aim of demonstrating that the rapid and sensible optical response can be processed to determine and display instantly the concentration of substance.
The results of this thesis dissertation were reported on six manuscripts published in peerreview indexed journals, five presentations in international conferences, and a patent filed to the Colombian Superintendence of Industry and Commerce. These products constitute the core of the present thesis. | |
dc.description.abstract | El trabajo investigativo llevado a cabo para la producción de esta tesis de doctorado tiene como objetivo fundamental el desarrollo de una plataforma de sensado soportado en tecnología de fibra óptica que permite la detección de especies químicas y biológicas a bajas concentraciones. Este trabajo se presenta como una alternativa de solución al problema que plantea la falta tecnología portátil de sensado en Colombia, que permita hacer medición in situ y en no más de un minuto de bajas concentraciones de sustancias, particularmente de muestras biológicas como la albúmina de suero bovino o la especie Mycobacterium tuberculosis y los niveles de mercurio en el agua. En respuesta a que las técnicas actuales robustas y rápidas de detección y análisis de sustancias, a baja concentraciones, requieren por lo general de equipos costosos, personal especializado y son poco portátiles, lo que difícilmente contribuye a su aplicación en campo y limita la posibilidad de llegar a las poblaciones vulnerables. En el desarrollo de esta tesis, que parte de una revisión detallada del estado del arte de la problemática de detección y monitoreo de especies químicas como el mercurio en agua y de especies biológica como la Mycobacterium tuberculosis, se evalúan, modelan, diseñan y construyen sensores interferométricos de bajo costo a fibra óptica que pueden ser funcionalizados para hacer reconocimiento químico o biológico específico de la sustancia a detectar. Se estudian, se implementan y se evalúan protocolos de activación y funcionalización que dotan de selectividad en la detección a los sensores desarrollados. Adicionalmente, se evalúa la implementación de los sensores interferométricos en una plataforma diseñada que permite procesar en segundos la respuesta óptica y la transduce en una medida de la concentración de sustancia. Los resultados de esta tesis de doctorado fueron consolidados en seis manuscritos publicados en revistas indexadas de circulación internacional, cinco presentaciones en eventos internacionales y una solicitud de patente ante la Superintendencia de Industria y Comercio de Colombia. Estos productos constituyen el núcleo de la presente tesis. (Texto tomado de la fuente) | |
dc.language | eng | |
dc.publisher | Universidad Nacional de Colombia | |
dc.publisher | Medellín - Ciencias - Doctorado en Ciencias - Física | |
dc.publisher | Facultad de Ciencias | |
dc.publisher | Medellín, Colombia | |
dc.publisher | Universidad Nacional de Colombia - Sede Medellín | |
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dc.rights | Atribución-NoComercial-CompartirIgual 4.0 Internacional | |
dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Fiber optics sensing platform for monitoring biological and chemical species at low-concentrations | |
dc.type | Trabajo de grado - Doctorado | |