bachelorThesis
Uso de Levosimendán en el postoperatorio de cirugía cardiaca.
Date
2010Registration in:
. Gillies M., Bellomo R, et al. Bench-to-bedside review: Inotropic drug therapy after
adult cardiac surgery – a systematic literature review. Crit Care. 2005 Jun;9(3):266-
79
Papp Z., Csapó K., et al. Pharmacological mechanisms contributing to the clinical
efficacy of levosimendan. Cardiovasc Drug Rev. 2005 Spring; 23(1):71-98.
Nieminen MS, Böhm M, et al. Executive summary of the guidelines on the diagnosis
and treatment of acute heart failure: the Task Force on Acute Herat Failure of the
Eur Heart J. 2008; 29: 2388 - 442
Raja S., Rayen B. Levosimendan in Cardiac Surgery: Current Best: Available
Evidence. Ann Thorac Surg. 2006 Apr; 81(4):1536-46.
Salmenperä M, Eriksson H., et al. Levosimendan in perioperative and critical care
patients. Curr Opin Anaesthesiol. 2009 Aug; 22(4):496-501.
Opie L. Braunwald Heart Disease Cardiovascular. 8a Edición, 2007. Capítulo 21:
Mecanismos de la contracción y la relajación cardiaca
Cardiovascular Physiology. Lange. 5a Edición, 2005. Capítulo 2: Características de
las células musculares cardiacas
Butler J, Giamouzis G, et al. A struggle to SURVIVE: to abandon or not to abandon
levosimendan? Cardiovasc Drugs Ther 2007 Oct;21(5):401-2.
Archan S, Toller W, et al. Levosimendan: current status and future prospects. Curr
Opin Anaesthesiol 2008 Feb;21(1):78-84.
Delaney A, Bradford C, et al. Levosimendan for the treatment of acute severe heart
failure: A meta-analysis of randomised controlled trials. Int J Cardiol. 2010 Feb
4;138(3):281-9
Rehberg S, Ertmer C, et al. Role of Levosimendan in intensive care treatment of
myocardial insufficiency. Anaesthesist 2007 Jan;56(1):30-43.
Toller WG, Stranz C. Levosimendan, a new inotropic and vasodilator agent.
Anesthesiology 2006 Mar;104(3):556-69.
Yildiz O. Vasodilating mechanisms of levosimendan: involvement of K+ channels. J
Pharmacol Sci 2007 May;104(1):1-5.
Soedeing P. Inoprotection: the perioperative role of levosimendan. Anesth Intensive
Care. 2007 Dec; 35(6):845-62.
Álvarez J., Taboada M., et al. Efectos hemodinámicos del levosimendan en el
postoperatorio de pacientes sometidos a cirugía cardiaca. Rev Esp Anestesiol
Reanim. 2005; 52: 389-94
Duygu H, Ozerkan F, et al. Effect of levosimendan on right ventricular systolic and
diastolic functions in patients with ischaemic heart failure. Int J Clin Pract 2008
Feb;62(2):228-33.
Delle Karth G, Buberl A, et al. Hemodynamic effects of a continuous infusion of
levosimendan in critically ill patients with cardiogenic shock requiring
catecholamines. Acta Anaesthesiol Scand 2003 Nov;47(10):1251-6.
Russ MA, Prondzinsky R, et al. Hemodynamic improvement following levosimendan
treatment in patients with acute myocardial infarction and cardiogenic shock. Crit
Care Med 2007 Dec;35(12):2732-9.
Pinto, B., Rehberg S., et al. Role of levosimendan in sepsis and septic shock. Curr
Opin Anesthesiol 2008 Apr;21(2):168-77.
Tritapepe L, De Santis V, et al. Preconditioning effects of levosimendan in coronary
artery bypass grafting--a pilot study. Br J Anaesth 2006 Jun;96(6):694-700
De Hert SG, Lorsomradee S, et al. The effects of levosimendan in cardiac surgery
patients with poor left ventricular function. Anesth Analg 2007 Apr;104(4):766-73.
Tasouli A, Papadopoulos K, et al. Efficacy and safety of perioperative infusion of
levosimendan in patients with compromised cardiac function undergoing open-heart
surgery: importance of early use. Eur J Cardiothorac Surg 2007 Oct;32(4):629-33.
Levin R., Degrange M. The Calcium Sensitizer Levosimendan Gives Superior
Results to Dobutamine in Postoperative Low Cardiac Output Syndrome. Rev Esp
Cardiol 2008 May;61(5):471-9.
Kerbaul F, Rondelet B, et al. Effects of levosimendan versus dobutamine on
pressure load-induced right ventricular failure. Crit Care Med 2006
Nov;34(11):2814-9.
Follath F, Cleland JG., et al. Efficacy and safety of intravenous levosimendan
compared with dobutamine in severe low-output heart f Lancet 2002, Jul;
360(9328):196-202.
Moiseyev VS, Poder P., et al. Safety and efficacy of a novel calcium sensitizer,
levosimendan, in patients with left ventricular failure due to an acute myocardial
infarction. A randomized, placebo-controlled, double-blind study (RUSSLAN). Eur
Heart J 2002 Sep;23(18):1422-32.
Johansson S, et al. Effect of levosimendan treatment on length of hospital and
intensive care stay in the REVIVE I study. Crit Care 2004; 8 Sup 1: 88.
Landoni G. et al. Reducing mortality in cardiac surgery with Levosimendan: A
Meta-analysis of Randomized Controlled Trials. J Cardiothorac Vasc Anesth. 2010
Feb;24(1):51-7.
Aksun N, Karahan M. et al. Timing of levosimendan in cardiac surgery. Anadolu
Kardiyol Derg. 2009 Jun;9(3):223-30.
De Santis V., Vitale D. et al. Levosimendan and cardiac surgery. Cardiothorac Vasc
Anesth. 2010 Feb;24(1):210.
Nieminen MS, Pollesello P, et al. Effects of levosimendan on the energy balance:
preclinical and clinical evidence. J Cardiovasc Pharmacol. 2009 Apr; 53(4):302-10.
129265
TE01309
Author
Buitrago Bernal, Ricardo Antonio
Institutions
Abstract
Levosimendán es inotrópico y vasodilatador, con mecanismo de acción diferente, utilizado en falla cardiaca. En cirugía cardiaca la literatura es limitada, sin concluir efectividad e impacto en morbimortalidad. Este trabajo muestra el comportamiento hemodinámico y de perfusión tisular de pacientes con disfunción ventricular en postoperatorio, usando Levosimendán. 78 pacientes recibieron infusión de 0.1 mcg/kg/min; se recolectaron parámetros hemodinámicos y de perfusión tisular antes, durante y al finalizar la infusión para análisis descriptivo. Se observó aumento en índice cardiaco, disminución en presión capilar pulmonar; aumento en saturación venosa de oxígeno, disminución en Da-vO2, delta de CO2, tasa de extracción y base exceso. En este grupo de pacientes se observó mejoría en perfil hemodinámico y perfusión tisular, tras la infusión.