info:eu-repo/semantics/article
Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
Fecha
2015-07-30Registro en:
1420-3049
Molecules
Autor
Cedrón, Juan C.
Ravelo, Ángel G.
León, Leticia G.
Padrón, José M.
Estévez-Braun, Ana
Institución
Resumen
The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.