info:eu-repo/semantics/article
TOCOSH FLOUR (Solanum tuberosum L.): a toxicological assessment of traditional peruvian fermented potatoes
Fecha
2020Registro en:
2304-8158
Foods
Autor
Velasco Chong, Jonas Roberto
Oscar Herrera Calderón
Juan Pedro Rojas Armas
Renán Dilton Hañari Quispe
Renán Dilton Hañari Quispe
Gilmar Peña Rojas
Vidalina Andía Ayme
Vidalina Andía Ayme
Andres F. Yepes Perez
Cristian Aguilar
Institución
Resumen
Potato tocosh is a naturally processed potato for nutritional and curative purposes from
traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity
of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28
days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality,
body weight variations, and histological analysis. At the end of treatment, relative organ weights,
histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was
administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body
weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute
toxicity showed that the median lethal dose (LD50) value of TF is higher than 2000 g/kg BW but less than
5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For
sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000
g/kg BW. There were statistically significant differences in body weight, and relative organ weight in
the stomach and brain. No differences in hematological and biochemical parameters were observed
when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor
abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional
Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats.