Article
Enterococcus faecalis Infective Endocarditis: Is It Time to Abandon Aminoglycosides?
Fecha
2013Registro en:
Clinical Infectious Diseases, 2013, 56(9):1269–72
Autor
Munita, José
Arias, Cesar A.
Murray, Barbara E.
Institución
Resumen
Since the first description of enterococcal infective endocarditis (IE) in 1899 and the subsequent availability of antibiotics for the treatment of this life-threatening infection, clinicians have faced important challenges in the management of this disease Enterococci exhibit intrinsic antibiotic resistance (eg, to cephalosporins , clindamycin), are less susceptible to various antibiotics (eg, β-lactams) that are active against streptococci and staphylococci, and are often tolerant to compounds (penicillin) that normally have a bactericidal effect against other susceptible bacteria.The lack of efficacy of penicillin for many cases of enterococcal IE sparked interest in possible alternative therapies.