Preprint
Modeling Parkinson's Disease Heterogeneity to Accelerate Precision Medicine
Fecha
2019Registro en:
Trends Mol Med. 2019 Dec;25(12):1052-1055. doi: 10.1016/j.molmed.2019.09.004.
Autor
Olivares, Gonzalo
Olguín, Patricio
Klein, Andrés
Institución
Resumen
mechanistic understanding of the diverse clinical manifestations of Parkinson's disease (PD) and variable patient response to treatments is lacking. Genetically diverse PD model organisms can be used to map modifier genes and understand clinically relevant phenotypes of varying severity. This strategy can accelerate the pace of discoveries for precision medicine purposes.