Reactivation and foetal infection in pregnant heifers infected with neospora caninum live tachyzoites at prepubertal age

dc.creatorHecker, Yanina
dc.creatorBurucúa, Mercedes María
dc.creatorFiorani, Franco
dc.creatorMaldonado Rivera, Jaime
dc.creatorCirone, Karina Mariela
dc.creatorDorsch, Matías
dc.creatorCheuquepan Valenzuela, Felipe
dc.creatorCampero, Lucia Maria
dc.creatorCanton, German Jose
dc.creatorMarín, Maia
dc.creatorOrtega Mora, Luis
dc.creatorMoore, Prando Dadin
dc.date.accessioned2022-08-04T11:39:47Z
dc.date.accessioned2023-03-15T14:16:33Z
dc.date.available2022-08-04T11:39:47Z
dc.date.available2023-03-15T14:16:33Z
dc.date.created2022-08-04T11:39:47Z
dc.date.issued2022-07-25
dc.identifier2076-393X
dc.identifierhttps://doi.org/10.3390/vaccines10081175
dc.identifierhttp://hdl.handle.net/20.500.12123/12494
dc.identifierhttps://www.mdpi.com/2076-393X/10/8/1175
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6215447
dc.description.abstractNeospora caninum is recognised for causing cattle abortion, provoking severe economic losses in the livestock industry worldwide. The aim of the present study was to evaluate the reactivation and foetal infection in pregnant heifers inoculated with live N. caninum tachyzoites before puberty. A total of 15 30-month-old pregnant heifers were allocated into four groups: animals inoculated with live tachyzoites of NC-Argentina LP1 isolate before puberty and challenged with live tachyzoites of NC-1 strain at 210 days of gestation (DG) (Group A); animals mock inoculated before puberty and challenged with NC-1 strain at 210 DG (Group B), animals inoculated before puberty but not subsequently challenged (Group C); and noninfected and nonchallenged animals (Group D). The results of this study showed that 100% of animals infected before puberty (Groups A and C) suffered reactivation of the infection at the seventh month of gestation. In addition, in three and two calves from Groups A and C, respectively, congenital infection was confirmed. Interestingly, we provide evidence that the use of live N. caninum tachyzoites in young animals as a strategy to induce protection is neither safe nor effective.
dc.languageeng
dc.publisherMDPI
dc.relationinfo:eu-repograntAgreement/INTA/PNSA-1115053/AR./Biotecnologías reproductivas y desarrollo de metodologías de diagnóstico, control y prevención de las enfermedades infecciosas y parasitarias que afectan la concepción, gestación y período neonatal en especies de interés zootécnico.
dc.relationinfo:eu-repograntAgreement/INTA/2019-PD-E5-I102-001/2019-PD-E5-I102-001/AR./Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceVaccines 10 (8) : 1175 (2022)
dc.subjectGanado Bovino
dc.subjectNeospora Caninum
dc.subjectInoculación
dc.subjectParásitos
dc.subjectInfección Experimental
dc.subjectSeguridad
dc.subjectEficacia
dc.subjectCattle
dc.subjectInoculation
dc.subjectParasites
dc.subjectExperimental Infection
dc.subjectSafety
dc.subjectEfficiency
dc.titleReactivation and foetal infection in pregnant heifers infected with neospora caninum live tachyzoites at prepubertal age
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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