info:ar-repo/semantics/artículo
Genetic characterization of bovine herpesvirus 4 (BoHV-4) isolates from Argentine cattle suggests a complex evolutionary scenario
Fecha
2020-04Autor
Perez, Sandra
Manrique, Julieta
Moran, Pedro
Romeo, Florencia
Angelini, Hernán Pablo
Leunda, Maria Rosa
Pereyra, Susana Beatriz
Spetter, Lucas Maximiliano
Gonzalez Altamiranda, Erika
Odeon, Anselmo Carlos
Jones, Leandro
Verna, Andrea Elizabeth
Resumen
Bovine herpevsirus 4 (BoHV-4) is a gammaherpesvirus that has been associated with different clinical conditions in cattle. In Argentina, BoHV-4 was detected in diverse bovine samples. The aim of this study was to analyze the genetic relationship of 48 field BoHV-4 strains isolated from cattle in Argentina. According to thymidine kinase (tk) gene sequences, BoHV-4 isolates belong to genotypes 1, 2 and 3. Phylogenetic analyses confirmed the presence of the three previously described viral genotypes. However, some of the studied isolates presented conflicting phylogenetic signals between the studied markers. This suggests a complex evolutionary background, that is a history of recombination, incomplete lineage sorting (deep coalescence) or a combination of these, which requires further study. These potential events make difficult the diagnosis of BoHV-4 from clinical samples of cattle and may pose a significant problem for the control of the virus in the herds.