Chicken egg yolk antibodies against bovine respiratory syncytial virus neutralize the virus in vitro

Ferella, Alejandra; Bellido, Demian; Chacana, Pablo; Wigdorovitz, Andres; Dus Santos, Maria Jose; Mozgovoj, Marina Valeria

info:ar-repo/semantics/artículo

Date

2012

Registration in:

1877-282X

https://doi.org/10.1016/j.provac.2012.04.006

http://hdl.handle.net/20.500.12123/4935

https://www.sciencedirect.com/science/article/pii/S1877282X12000082

https://repositorioslatinoamericanos.uchile.cl/handle/2250/6208106

Author

Ferella, Alejandra

Bellido, Demian

Chacana, Pablo

Wigdorovitz, Andres

Dus Santos, Maria Jose

Mozgovoj, Marina Valeria

Institutions

Instituto Nacional de Tecnología Agropecuaria (Argentina)

Abstract

Bovine respiratory syncytial virus (BRSV) and its counterpart in humans (HRSV) are two closely related virus, which are the leading cause of severe respiratory syndrome in calves and young children, respectively. Passive immunization can be a practical alternative to conventional vaccination in order to prevent the disease. In this report the production of chicken egg yolk IgY and its ability to neutralize BRSV in vitro were assessed. Purified IgY against BRSV specifically recognized BRSV in a dot blot assay and was able to neutralize the virus in a viral neutralization assay. These results demonstrate the potential use of IgY as a prophylactic treatment against RSV infection.