info:ar-repo/semantics/artículo
Vaccination against δ-retroviruses : the bovine leukemia virus paradigm
Fecha
2014-06Autor
Gutierrez, Gerónimo
Rodriguez, Sabrina M.
de Brogniez, Alix
Gillet, Nicolas A.
Golime, Ramarao
Burny, Arsene
Jaworski, Juan Pablo
Alvarez, Irene
Vagnoni, Lucas Emilio
Trono, Karina Gabriela
Willems, Luc
Resumen
Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.