info:eu-repo/semantics/article
Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
Fecha
2016Registro en:
2036-6590 (Print)
1972-2680 (Online)
Autor
Garcia, Elizabeth Andrea
Bianco, María Veronica
Blanco, Federico Carlos
Bigi, Fabiana
Resumen
Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014)..