Artículos de revistas
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
Fecha
2022-01-01Registro en:
Journal of Stroke and Cerebrovascular Diseases, v. 31, n. 1, 2022.
1532-8511
1052-3057
10.1016/j.jstrokecerebrovasdis.2021.106187
2-s2.0-85118588226
Autor
Federal University of Triângulo Mineiro
Universidade Estadual Paulista (UNESP)
Institución
Resumen
Objective: Patterns of cytokine levels and their association with stroke severity, infarct size, and muscle strength are obscure. We aimed to analyze the immune mediators linked to T helper (Th)1, Th2, Th17, and regulatory T cell patterns and their association with stroke severity, infarct size, and muscle strength. Materials and methods: We included patients with acute stroke (n = 15) and healthy non-disabled individuals (n = 20) aged > 18 years. The dependent variables were stroke severity according to the National Institute of Health Stroke Scale (NIHSS), infarct size on computed tomography, handgrip strength by dynamometry, and global muscle strength according to the Medical Research Council (MRC) scale. The independent variables were the circulating cytokine levels. The cytokine levels were compared between the groups, and correlations between the clinical data were verified. Results: The stroke group had higher interleukin (IL)-6 (p < 0.0001) and IL-10 (p < 0.0001) levels, but lower tumor necrosis factor (TNF)-α (p = 0.036) levels than the control group. IL-10 and soluble tumor necrosis factor receptor (sTNF-RII) levels were correlated with each other (r = 0.533; p = 0.042) and infarct size (r = 0.653; p = 0.033 and r = 0.689; p = 0.018, respectively). MRC scores were positively and negatively correlated with handgrip strength of the affected side (r = 0.78; p = 0.001) and NIHSS scores (r = -0.87; p < 0.0001), respectively. Conclusions: Plasma levels of some cytokines were associated with changes in the acute phase of stroke, and IL-10 and sTNF-RII levels are potential biomarkers of infarct size.
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Characterization of patients with embolic strokes of undetermined source in the navigate esus randomized trial
Kasner, Scott E.; Lavados Germain, Pablo Manuel (Elsevier, 2018-06)Background: The New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial vs. ASA to Prevent Embolism in Embolic Stroke of Undetermined Source (NAVIGATE-ESUS) trial is a randomized phase-III trial comparing ... -
Stroke phases responses around maximal lactate steady state in front crawl
Pelarigo, Jailton G.; Denadai, Benedito S.; Greco, Camila C. -
Validation of the Scandinavian stroke scale in a multicultural population in Brazil
Luvizutto, Gustavo José; Monteiro, Tamiris Aparecida; Braga, Gabriel; Pontes-Neto, Octavio Marques; Lima Resende, Luiz Antônio de; Bazan, Rodrigo