Influence of free amino acids on clavulanic acid production by Streptomyces clavuligerus in synthetic medium

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2022-04-28T20:08:49Z
dc.date.accessioned2022-12-20T01:54:00Z
dc.date.available2022-04-28T20:08:49Z
dc.date.available2022-12-20T01:54:00Z
dc.date.created2022-04-28T20:08:49Z
dc.date.issued2006-09-20
dc.identifierBrazilian Archives of Biology and Technology, v. 49, n. SPEC. ISS., p. 173-179, 2006.
dc.identifier1516-8913
dc.identifierhttp://hdl.handle.net/11449/224800
dc.identifier2-s2.0-33748642778
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5404929
dc.description.abstractThe effect of nitrogen source on clavulanic acid production was investigated in shake flasks. Media containing asparagine plus one of several different amino acids or a combination of two amino acids was tested. The best result, ca. 180 mg/L clavulanic acid, CA, in 60 h, was obtained with the lysine-tyrosine pair. In an aerated and agitated fermentor this medium led to CA concentrations of ca. 210 mg/L, a remarkable production for synthetic medium utilization. Amino acids analysis during cultivation indicated that, while asparagine was consumed rapidly, lysine and tyrosine were metabolized slowly, promoting CA production.
dc.languageeng
dc.relationBrazilian Archives of Biology and Technology
dc.sourceScopus
dc.subjectAmino acids
dc.subjectB-lactamase inhibitor
dc.subjectClavulanic acid
dc.subjectS. clavuligerus
dc.subjectSynthetic medium
dc.titleInfluence of free amino acids on clavulanic acid production by Streptomyces clavuligerus in synthetic medium
dc.typeActas de congresos


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