Actas de congresos
The experimental chemical hardness in the interaction between β-tubulin and epothilone B
Fecha
2019-11-21Registro en:
Journal of Physics: Conference Series, v. 1403, n. 1, 2019.
1742-6596
1742-6588
10.1088/1742-6596/1403/1/012016
2-s2.0-85076685542
Autor
Universidad Industrial de Santander
Universidade Estadual Paulista (UNESP)
Institución
Resumen
We showed the use of the experimental chemical hardness in the analysis of the interaction between β-tubulin and epothilone B. The interaction is analyzed by exposing the Epothilone B to a sensor based on an organic self-assembled monolayer functionalized with Beta tubulin. The proposed methodology is nondestructive and label-free. It allows us to compare the interaction between Beta-tubulin and different concentrations of the pharmacological molecule, i.e., epothilone B. The interaction is analyzed by the experimental hardness obtained according to the Miranda-Bueno methodology. We observed a linear behavior between the logarithm of the chemical hardness and the logarithm of epothilone B concentration. The results suggest the experimental chemical hardness can be used to compare the interaction of β-tubulin with epothilone B and with other pharmacological molecules.