The GATA3 gene is involved in leprosy susceptibility in Brazilian patients

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2022-04-19T12:50:24Z
dc.date.accessioned2022-12-20T00:27:28Z
dc.date.available2022-04-19T12:50:24Z
dc.date.available2022-12-20T00:27:28Z
dc.date.created2022-04-19T12:50:24Z
dc.date.issued2016-04
dc.identifierhttp://hdl.handle.net/11449/217914
dc.identifier10.1016/j.meegid.2016.01.015
dc.identifier3866361546785080
dc.identifier0000-0002-0853-4715
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5397861
dc.description.abstractLeprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population.
dc.languageeng
dc.publisherScienceDirect
dc.relationInfection, Genetics and Evolution
dc.rightsAcesso aberto
dc.subjectAssociation study
dc.subjectGATA-3 transcription factor
dc.subjectGATA3
dc.subjectLeprosy
dc.subjectPolymorphisms
dc.subjectrs10905284
dc.titleThe GATA3 gene is involved in leprosy susceptibility in Brazilian patients
dc.typeArtículos de revistas


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